Table 5.

Multivariable-Adjusted Hazard Ratios (HRs) and 95% Confidence Intervals (CIs) of 1-Year Overall Cumulative Probability of Death for Patients Aged 65 and Older Diagnosed With Glioblastoma in All Included States^a, by Period of Diagnosis (2008–2010 and 2014–2016)

	Pre-expansion		Post-expansion		Interaction P value
	2008–2010		2014–2016
	N = 3887		N = 4640
	No. of deaths	HR (95% CI)	No. of deaths	HR (95% CI)
ACA status					.9745
Expansion states	689	Reference	601	Reference
Non-expansion states	2300	1.13 (1.03–1.23)	2353	1.14 (1.04–1.26)
Sex					.2496
Male	1599	Reference	1635	Reference
Female	1390	1.00 (0.93–1.07)	1319	0.94 (0.87–1.01)
Race					.489
Non-Hispanic white	2498	Reference	2438	Reference
Non-Hispanic black	140	0.89 (0.75–1.06)	121	0.77 (0.64–0.92)
Non-Hispanic American Indian/Alaska Native	5	0.48 (0.20–1.15)	6	1.09 (0.49–2.44)
Non-Hispanic Asian or Pacific Islander	103	0.75 (0.62–0.92)	128	0.84 (0.70–1.01)
Hispanic (all races)	235	0.97 (0.85–1.12)	257	0.93 (0.82–1.07)
Non-Hispanic unknown race	8	1.12 (0.55–2.28)	<5	0.69 (0.26–1.85)
Insurance status					.1665
Uninsured	19	0.79 (0.50–1.25)	19	1.08 (0.68–1.70)
Any Medicaid	227	0.94 (0.81–1.08)	194	1.02 (0.87–1.19)
Non-Medicaid insured	1983	Reference	2024	Reference
Insured/No specifics	648	1.01 (0.92–1.10)	611	0.99 (0.90–1.08)
Insurance status unknown	112	0.72 (0.59–0.89)	106	1.03 (0.84–1.27)
Tumor size at diagnosis					.1577
≤45 mm	1237	Reference	1299	Reference
>45 mm	1208	1.25 (1.16–1.36)	1203	1.15 (1.06–1.24)
Unknown	544	1.07 (0.97–1.19)	452	1.10 (0.98–1.23)

Cox regression models stratified by radiation and adjusted for surgery and chemotherapy.

^aAlaska (Natives), California, Connecticut, Georgia, Hawaii, Iowa, Kentucky, Louisiana, Michigan (Detroit), New Jersey, New Mexico, Utah, and Washington (Seattle).