Table 1 (suite).

Descriptive summary of 25 studies reporting the prevalence of birth defects and additional studies reporting the prevalence of sub types of birth defects among newborn in sub-Saharan African countries included in the systematic review and meta-analysis

Typeof birth defect	Author	Publication year	Country	African Region	Sample size	Case	Quality score (10 pts)	Prevalence Per 1000(95% CI)
Oro-facial clefts defects	Adane and Seyoum	2018	Ethiopia	Eastern Africa	19650	86	8	2.60(1.89, 3.31)
	Agbenorku et al.	2011	Ghana	Western Africa	4000	25	7	6.25(3.81, 8.69)
	Butali et al.	2014	Nigeria	Western Africa	4600000	2197	8	0.48(0.46, 0.50)
	Ekanem et al.	2008	Nigeria	Western Africa	127929	56	8	0.44(0.33, 0.55)
	Eshete et al.	2017	Ethiopia	Eastern Africa	18811316	8232	7	0.44(0.43, 0.45)
	Kesande et al.	2014	Uganda	Central Africa	25985	20	7	0.77(0.43,1.11)
	Kishimba RS et al.	2015	Tanzania	Eastern Africa	27230	11	6	0.40(0.16, 0.64)
	Kromberg J and Jenkins T	1982	South Africa	Southern Africa	29633	9	7	0.30(0.10, 0.50)
	Njamnshi et al.	2008	Cameroon	Central Africa	52710	98	7	1.86(1.49, 2.23)
	Onankpa and Adamu	2014	Nigeria	Western Africa	6578	5	6	0.76(0.09, 1.43)
	Rakotoarison et al.	2012	Madagascar	Eastern Africa	150973	73	8	0.48(0.37, 1.27)
	Suleiman et al.	2005	Sudan	Northeastern Africa	15890	13	7	0.82(0.37, 1.27)
	Taye et al.	2016	Ethiopia	Eastern Africa	319776	2076	8	6.49(6.21, 6.77)
Neural tube defects	Adane and Seyoum	2018	Ethiopia	Eastern Africa	19650	103	8	5.24(4.23, 6.25)
	Ahuka et al.	2006	D/R of congo	Central Africa	8824	17	6	1.93(1.01, 2.85)
	Buccimazza et al.	1994	South Africa	Southern Africa	516252	606		1.17(1.08, 1.26)
	Ekanem et al.	2008	Nigeria	Western Africa	127929	111	8	0.87(0.71, 1.03)
	Ekanem TB et al.	2011	Nigeria	Western Africa	39693	52	8	1.31(0.95, 1.67)
	Ekwochi et al.	2017	Nigeria	Western Africa	5830	14	7	2.40 (1.14,3.66)
	Gedefaw et al.	2018	Ethiopia	Eastern Africa	8677	109	8	12.56(10.22, 14.90)
	Iroha et al.	2001	Nigeria	Western Africa	22288	80	6	3.59(2.80, 4.38)
	Kishimba RS et al.	2015	Tanzania	Eastern Africa	27230	39	6	1.43(0.98, 1.88)
	Kromberg J and Jenkins T	1982	South Africa	Southern Africa	29633	73	7	2.46(1.90, 3.02)
	Mekonen et al.	2015	Ethiopia	Eastern Africa	1516	22	7	14.51(8.49, 20.53)
	Muga R et al.	2009	Kenya	Eastern Africa	7355	32	7	4.35(2.85, 5.85)
	Mukhtar-Yola M et al.	2005	Nigeria	Western Africa	13619	22	6	1.62(0.94, 2.30)
	Ochoga et al.	2018	Nigeria	Western Africa	843	28	8	33.21(21.11, 45.31)
	Omer et al.	2016	Sudan	Eastern Africa	36785	103	7	2.80(2.26, 3.34)
	Onankpa and Adamu	2014	Nigeria	Western Africa	6578	7	6	1.06(0.27, 1.85)
	Onyearugha C and Onyire B	2014	Nigeria	Western Africa	14446	8	7	0.55(0.17, 0.93)
	Sayed et al.	2008	South Africa	Southern Africa	79587	122	8	1.53(1.26, 1.80)
	Taye et al.	2016	Ethiopia	Eastern Africa	319776	1873	8	5.86(5.60, 6.12)
	Ugwu et al.	2007	Nigeria	Western Africa	7388	7	7	0.95(0.25, 1.65)
	Venter P et al.	1995	South Africa	Southern Africa	7617	33	6	4.33(2.86, 5.80)