Table 6.
Results for sensitivity analysis of rate constants in Section Hepatocytes (SH).
| Key enzymes/reactions | Abbreviation | Δ Hepatic fatty acids (μM) | Δ Hepatic triglyceride (μM) | Δ Plasma fatty acids (μM) | Δ Plasma triglyceride (μM) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| +10% | −10% | +10% | −10% | +10% | −10% | +10% | −10% | |||
| (1) | Fructokinase | KHK | 3.44 | –5.07 | 281.15 | –325.16 | 22.24 | –25.85 | 42.43 | –49.38 |
| (2) | Aldolase B | aldB | –18.87 | 17.80 | 152.01 | –211.55 | –6.23 | 1.98 | 13.24 | –22.06 |
| (3) | Triose phosphate isomerase | TPI | 0.00 | 0.00 | 0.78 | –0.94 | 0.00 | –0.01 | 0.18 | –0.19 |
| (4) | Triokinase | Tri | 0.00 | 0.00 | 0.03 | –0.05 | 0.00 | 0.00 | 0.01 | –0.01 |
| (5) | Pyruvate kinase | PK | 25.27 | –25.88 | 320.09 | –357.91 | 38.59 | –37.67 | 74.51 | –83.11 |
| (6) | Phosphoenolpyruvate carboxykinase | PEPCK | –16.05 | 18.33 | –222.74 | 241.06 | –22.97 | 27.00 | –52.58 | 57.29 |
| (7) | Pyruvate oxidation | PDC | 15.61 | –16.73 | 217.04 | –244.18 | 22.66 | –23.67 | 52.77 | –58.74 |
| (8) | Fatty acid synthesis | FAS | 12.14 | –13.14 | 168.42 | –190.44 | 19.23 | –20.28 | 38.78 | –43.83 |
| (9) | Beta-oxidation | boxi | –0.45 | 0.47 | –19.09 | 20.71 | –0.64 | 0.68 | –4.41 | 4.77 |
| (10) | Triglyceride synthesis | TGS | –7.18 | 7.36 | 96.77 | –112.67 | 1.07 | –1.90 | –25.38 | 26.82 |
| (11) | Lipolysis | Lply | 0.37 | –0.36 | –0.88 | 0.87 | 0.13 | –0.12 | 0.71 | –0.71 |