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. 2020 Jul 27;2020(7):CD003146. doi: 10.1002/14651858.CD003146.pub4

Comparison 2. Hydroxyurea and phlebotomy versus standard treatment (transfusions/chelation).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
2.1 Clinical stroke ‐ Secondary prevention 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
2.2 Mortality 2   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
2.2.1 Mortality ‐ Primary prevention 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
2.2.2 Mortality ‐ Secondary prevention 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
2.3 Transfusion‐related complications ‐ Serum ferritin; Primary prevention 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
2.4 Transfusion related complications ‐ Liver iron concentration ‐ Primary prevention 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
2.5 Other neurological event 2   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
2.5.1 TIA ‐ Primary prevention 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
2.5.2 TIA ‐ Secondary prevention 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
2.6 Other sickle cell related complications 2   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
2.6.1 Total SCD‐related SAEs ‐ Secondary prevention 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
2.6.2 Acute chest syndrome ‐ Primary prevention 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
2.6.3 Acute chest syndrome ‐ Secondary prevention 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
2.6.4 Painful crisis ‐ Primary prevention 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
2.6.5 Painful crisis ‐ Secondary prevention 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
2.6.6 Infections and infestations SAEs ‐ Primary prevention 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
2.6.7 Infections and infestations SAEs ‐ Secondary prevention 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
2.7 Haemoglobin levels 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
2.8 Haemoglobin S levels 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected