Table 1.

Genes involved in ferroptosis amino acid metabolism.

Gene	Related protein	Regulation	Effect on ferroptosis	Reference
SLC7A11	Solute carrier family 7 member 11	Knockdown: prevent cystine uptake	Promote	(Jiang et al., 2015a; Dixon et al., 2012)
CARS	Cysteinyl-tRNA synthetase	Knockout: promote the sulfur transfer pathway	Inhibit	(Hayano et al., 2016)
CBS	Cystathionine β-synthase	Knockout: inhibit the conversion of homocysteine to cysteine	Promote	(Hayano et al., 2016)
GLS2	Glutaminase 2	Knockdown: inhibit the conversion of glutamine to glutamate	Inhibit	(Gao et al., 2015)
GOT1	Glutamic-oxaloacetic transaminase 1	Knockdown: inhibit the synthesis of α-KG	Inhibit	(Gao et al., 2015)
GCLC	Glutamate-cysteine ligase	Knockdown: prevent GSH biosynthesis	Promote	(Yang et al., 2014)