Table 2.

Genes involved in ferroptosis lipid metabolism.

Gene	Related protein	Regulation	Effect on ferroptosis	Reference
ACSL4	acyl-CoA synthetase long-chain family member 4	Knockout: prevent PUFAs-COA formation	Inhibit	(Kagan et al., 2017)
Lpcat3	lysophosphatidylcholine acyltransferase 3	Knockout: prevent PUFAs-COA from being incorporated into phospholipids	Inhibit	(Kagan et al., 2017)
Gpx4	glutathione peroxidase 4	Knockout: prevent the reduction of lipid hydroperoxides (PUFAs-OOH) to lipid alcohols (PUFAs-OH)	Promote	(Yang et al., 2014)
LOX	Lipoxygenases (lipoxygenase-12/15)	Knockout: prevent the dioxygenation of free and esterified PUFAs	Inhibit	(Yang et al., 2016)
AKR1C	aldo-keto reductase family 1 member C1	Upregulation: promote the elimination of end products of lipid peroxidation	Inhibit	(Dixon et al., 2014)
ACSF2	acyl-CoA synthetase family member 2	Knockdown: prevent the formation of specific lipid precursors in mitochondrial fatty acid metabolism.	Inhibit	(Dixon et al., 2012)
CS	Citrate synthase	Knockdown: prevent the formation of specific lipid precursors in mitochondrial fatty acid metabolism.	Inhibit	(Dixon et al., 2012)
SQS	squalene synthase	Knockdown: prevent the depletion of antioxidant CoQ10	Inhibit	(Shimada et al., 2016)