Table 3.

Genes involved in ferroptosis iron metabolism.

Gene	Related protein	Regulation	Effect on ferroptosis	Reference
TFRC (TfR1)	Transferrin receptor	Upregulation: increase unstable iron intake	Promote	(Yang and Stockwell, 2008)
NCOA4	Nuclear receptor coactivator 4	Knockdown: prevent degradation of ferritin in the autophagy pathway	Inhibit	(Hou et al., 2016; Mancias et al., 2014)
IREB2	iron response element-binding protein 2	Knockdown: regulate the translation and stability of iron consumption-related mRNAs	Inhibit	(Dixon et al., 2012)
ATG13	Autophagy related protein 13	Knockdown: prevent degradation of ferritin in the autophagy pathway	Inhibit	(Gao et al., 2016)
FTH1	Ferritin heavy chain 1	Knockdown: reduce major iron storage proteins in cells	Promote	(Yang and Stockwell, 2008)
HMOX1	heme oxygenase 1	Upregulation: promote heme degradation and free iron release	Promote	(Kwon et al., 2015)
PHKG2	phosphorylase kinase, γ2	Knockdown: indirectly promote iron depletion	Inhibit	(Yang et al., 2016)
HSPB1	heat shock protein beta-1	Knockdown: increase iron absorption	Promote	(Sun et al., 2015)
FANCD2	Fanconi anemia complementation group D2	Knockdown: increase iron absorption	Promote	(Song et al., 2016)
CISD1	CDGSH iron sulfur domain 1	Knockdown: inhibit mitochondrial iron uptake	Promote	(Yuan et al., 2016)
Fpn	ferroportin	Upregulation: promote the export of iron	Inhibit	(Zhao et al., 2018)