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. 2020 Jul 22;11:1061. doi: 10.3389/fphar.2020.01061

Table 4.

Tumor cells sensitive to ferroptosis.

Cancer type Therapeutic Type of evidence Reference
Hepatocellular carcinoma Erastin Cell culture (Dixon et al., 2012)
Sorafenib Cell culture; Cancer cells from patients (Lachaier et al., 2014)
Solasonine Cell culture; Mice xenotransplantation model (Jin et al., 2020)
Gastric carcinoma Erastin Cell culture (Wang et al., 2016)
Sulfasalazine(SAS) Cell culture (Okazaki et al., 2018)
Buthionine sulfoximine (BSO) Cell culture (Wang et al., 2016)
Ovarian carcinoma Erastin Cell culture (Zhou et al., 2019)
Artesunate Cancer cells from patients (Greenshields et al., 2017)
Pancreatic carcinoma Erastin Cell culture (Ohman et al., 2016)
Artesunate Cell culture (Eling et al., 2015)
Sorafenib Cell culture (Lachaier et al., 2014)
Piperlongumine Cell culture (Yuki et al., 2018)
Breast carcinoma Erastin Cell culture (Ma S. et al., 2017)
Siramesine Cell culture (Ma S. et al., 2017)
Lapatinib Cell culture (Ma S. et al., 2017)
Sulfasalazine(SAS) Cell culture (Yu et al., 2019)
Colorectal carcinoma Erastin Cell culture;
Mice xenotransplantation model
(Jiang et al., 2015b)
Sorafenib Cell culture (Lachaier et al., 2014)
Melanoma BAY 87-2243 Cell culture;
Mice xenotransplantation model
(Schöckel et al., 2015)
Sorafenib Cell culture;
Mice xenotransplantation model
(Lachaier et al., 2014)
Head and neck cancer Artesunate Cell culture;
Mice xenotransplantation model
(Roh et al., 2017)
Kidney carcinoma Erastin Cell culture;
Mice xenotransplantation model
(Jiang et al., 2015b)
Sorafenib Cell culture (Lachaier et al., 2014)
Lung carcinoma Sorafenib Cell culture (Lachaier et al., 2014)
Glioblastoma Temozolomide Cell culture;
Mice xenotransplantation model
(Buccarelli et al., 2018)
Lymphoma Sulfasalazine (SAS) Cell culture;
Mice xenotransplantation model
(Gout et al., 2001)
Retinoblastoma Sorafenib Cell culture;
Mice xenotransplantation model
(Louandre et al., 2015; Krainz et al., 2016)