Cairncross 2006.
| Study characteristics | ||
| Methods | Randomized controlled trial | |
| Participants | 289 AO or AOA 2 of 5 anaplastic features | |
| Interventions | Surgery + PCV + RT vs. surgery + RT | |
| Outcomes | Overall survival Progression‐free survival Toxicity Quality of life | |
| Notes | ||
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | Quote: ''Patients were (...) randomly assigned.'' Comment: probably done. |
| Allocation concealment (selection bias) | Low risk | Quote: ''Patients were stratified by age less than 50 versus ≥ 50 years, KPS 60 to 70 versus > 80, and moderately anaplastic versus highly anaplastic.''; ''Random assignment was performed by randomised permutated block within each stratification cell.'' Comment: probably done. |
| Blinding (performance bias and detection bias) All outcomes | High risk | Not blinded. |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | No mention of loss to follow‐up. |
| Selective reporting (reporting bias) | Low risk | Outcomes reported adequately. |