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. 2020 Jul 2;46(3):989–1002. doi: 10.3892/ijmm.2020.4666

Figure 6.

Figure 6

miR-589-3p mimic inhibited the migratory and invasive abilities of breast cancer cells by down-regulating IGF1R expression. (A-D) Wound healing assay was used to detect the migratory ability of MCF-7 and MDA-MB-231 cells. (E-H) Transwell assay was used to detect the invasive ability of MCF-7 and MDA-MB-231 cells. All experiments were repeated three times. **P<0.01 vs. NC; ##P<0.01 vs. IGF1R; ΘΘP<0.01 vs. IGF1R + miR-589-3p mimic; ΔΔP<0.01 vs. siNC; ρρP<0.01 vs. si-IGF1R; ΓΓP<0.01 vs. si-IGF1R + miR-589-3p inhibitor. IGF1R, insulin-like growth factor 1 receptor; miR, microRNA; NC, negative control; si, small interfering.