Brown 2010.

Methods	Before and after feasibility study
Participants	48 but data on 30 Mean age 68 (53 to 91) 19 males and 11 females All advanced cancer UK
Interventions	Blood transfusion
Outcomes	Primary: Fatigue measured on FACT‐F Scale pre and at 24 hours and 3 days later. Outcome looking for a minimally significant clinical response (drop of 3 points on the scale). Fatigue measured on the Brief Fatigue Inventory (BFI) with predetermined outcome. 21/30 patients had a minimally clinical significant response according to the FACT‐F scale. Number of patients with a worst fatigue score of 7 or more on the BFI fell from 27/30 patients pre transfusion to 15/30 after. 22/30 reported that the transfusion had helped their fatigue, 3 were unsure and 5 recorded no noticeable difference Secondary: Pre mean Hb 7.96 g/dl; no post measurements; mean units transfused 2.53 No survival data
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	High risk	Before and after study so no blinding