Comparison 4. SFA reduction vs usual diet ‐ secondary outcomes including potential adverse effects.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
4.1 Cancer diagnoses	4	52294	Risk Ratio (M‐H, Random, 95% CI)	0.94 [0.83, 1.07]
4.2 Cancer deaths	5	52283	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.61, 1.64]
4.3 Weight, kg	6	43062	Mean Difference (IV, Random, 95% CI)	‐1.77 [‐3.54, ‐0.01]
4.4 BMI, kg/m2	6	43894	Mean Difference (IV, Random, 95% CI)	‐0.42 [‐0.72, ‐0.12]
4.5 Systolic Blood Pressure, mmHg	5	3812	Mean Difference (IV, Random, 95% CI)	‐0.19 [‐1.36, 0.97]
4.6 Diastolic Blood Pressure, mmHg	5	3812	Mean Difference (IV, Random, 95% CI)	‐0.36 [‐1.03, 0.32]
4.7 Quality of Life	1	40130	Mean Difference (IV, Random, 95% CI)	0.04 [0.01, 0.07]