ICFAMED.

Methods	A Mediterranean diet for preventing heart failure and atrial fibrillation in hypertensive patients (ICFAMED) RCT, 24 months
Participants	People with hypertension aged 55 to 75 years at high cardiovascular risk, but without existing CVD
Interventions	MedDiet: Mediterranean‐style diet, dietary advice (individual and group) every three months LFD: Low‐fat diet according to American Heart Association guidelines, dietary advice (individual and group) every three months
Outcomes	Primary: heart failure and/or atrial fibrillation Secondary: echocardiographic variables & BP variables Actual outcomes from abstracts: MedDiet: 5 CVD events (atrial fibrillation (AF) 2; ischaemic heart disease (IHD) 2; stroke 1), LFD: 11 CVD events (AF 6, IHD 2, stroke 3). The crude rate for the occurrence of events per 1000 patient‐months of follow‐up was 197 (95% CI: 06–46) for MedDiet, 451 (95% CI: 3–8.1) for LFD. The HR for patients with MedDiet compared to LFD was 044 (95% CI: 015–126, P > 005).
Notes	Trials registration: ISRCTN27497769 Enrollment began in 2012; appears to have completed in 2017; abstract and poster publications only to date Awaiting assessment because: Unclear whether one arm was higher in saturated fat than the other, awaiting fuller publication to assess

^{AF: atrial fibrillation
CVD: cardiovascular disease
HR: hazard ratio
ICFAMED: A Mediterranean diet for preventing heart failure and atrial fibrillation in hypertensive patients
IHD: Ischaemic heart disease
LFD: low fat diet
MedDiet: Mediterranean style diet
RCT: randomised controlled trial}