Palagiano 1994.

Study characteristics
Methods	Trial design: Randomised, open study
Participants	Participants: 50 women were randomised, 47 were analysed Age: 20‐40 Inclusion criteria: Laparoscopically diagnosed endometriosis No treatment for endometriosis within previous 12 months Exclusion criteria: Setting: Italy Timing:
Interventions	Leuprolide acetate 3.75mg IM monthly for 6 months (n=30) versus Danazol 600mg OD PO for 6 months (n=20)
Outcomes	Dysmenorrhoea, dyspareunia, pelvic pain Adverse effects
Notes	Intention‐to‐treat analysis: Sample size calculation: Funding: Authors contacted regarding methods and replied
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"randomly allocated"
Allocation concealment (selection bias)	Low risk	Randomisation done by a pharmacy
Blinding (performance bias and detection bias) All outcomes	High risk	Open study
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Withdrawals after randomisation <10% "drop out patients without M.D. consultation"
Selective reporting (reporting bias)	Low risk	All primary outcomes stated were reported on