Comparison 3. Function.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 ADCS‐ADL (change from baseline)	3	1243	Mean Difference (IV, Random, 95% CI)	1.00 [‐1.15, 3.15]
2 ADCS‐ADL (change from baseline at 26 weeks)	2	581	Mean Difference (IV, Random, 95% CI)	1.81 [‐1.01, 4.63]
3 ADCS‐ADL (change from baseline at 52 weeks)	2	845	Mean Difference (IV, Random, 95% CI)	1.84 [‐1.00, 6.68]