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| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 NPI (change from baseline) | 3 | 1243 | Mean Difference (IV, Fixed, 95% CI) | ‐1.77 [‐3.09, ‐0.45] |
| 2 NPI (change from baseline at 26 weeks) | 2 | 581 | Mean Difference (IV, Fixed, 95% CI) | ‐2.51 [‐4.24, ‐0.79] |
| 3 NPI (change from baseline at 52 weeks) | 2 | 845 | Mean Difference (IV, Fixed, 95% CI) | ‐1.61 [‐3.27, 0.06] |
