Comparison 5. Adverse events.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Adverse Events	4	1034	Risk Ratio (M‐H, Fixed, 95% CI)	1.03 [0.93, 1.14]
2 Serious Adverse Events	4	1034	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.55, 1.35]