Database	Time span	Search strategy
The Cochrane Hepato‐Biliary Group Controlled Trials Register	April 2020	(antibiotic* or ampicillin* or cefazolin* or cefepime* or cefotaxime* or cefotiam* or ceftacidim* or ceftazidim* or ceftriaxone* or cefuroxim* or celastin* or cilastin* or ciprofloxacin* or daptomycin* or imipenem* or imipinem* or impenem* or impinem* or levofloxacin* or linezolid* or meropenem* or metronidazole* or moxifloxacin* or piperacillin* or sulbactam* or tacobactam* or vancomycin*) AND (cholangit* or cholecystit*)
Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library	2020, Issue 4	#1 MeSH descriptor: [Anti‐Bacterial Agents] explode all trees #2 MeSH descriptor: [Ampicillin] explode all trees #3 MeSH descriptor: [Cephalosporins] explode all trees #4 MeSH descriptor: [Ciprofloxacin] explode all trees #5 MeSH descriptor: [Daptomycin] explode all trees #6 MeSH descriptor: [Thienamycins] explode all trees #7 MeSH descriptor: [Levofloxacin] explode all trees #8 MeSH descriptor: [Linezolid] explode all trees #9 MeSH descriptor: [Metronidazole] explode all trees #10 MeSH descriptor: [Moxifloxacin] explode all trees #11 MeSH descriptor: [Sulbactam] explode all trees #12 MeSH descriptor: [Vancomycin] explode all trees #13 (antibiotic* or ampicillin* or cefazolin* or cefepime* or cefotaxime* or cefotiam* or cefta*idim* or ceftriaxone* or cefuroxim* or celastin* or cilastin* or ciprofloxacin* or daptomycin* or imip*nem* or imp*nem* or levofloxacin* or linezolid* or meropenem* or metronidazole* or moxifloxacin* or piperacillin* or sulbactam* or tacobactam* or vancomycin*) #14 #1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9 or #10 or #11 or #12 or #13 #15 MeSH descriptor: [Cholangitis] explode all trees #16 MeSH descriptor: [Cholecystitis] explode all trees #17 (cholangit* or cholecystit*) #18 #15 or #16 or #17 #19 #14 and #18
MEDLINE Ovid	1946 to April 2020	1. exp Anti‐Bacterial Agents/ 2. exp Ampicillin/ 3. exp Cephalosporins/ 4. exp Ciprofloxacin/ 5. exp Daptomycin/ 6. exp Thienamycins/ 7. exp Levofloxacin/ 8. exp Linezolid/ 9. exp Metronidazole/ 10. exp Moxifloxacin/ 11. exp Sulbactam/ 12. exp Vancomycin/ 13. (Ampicillin* or cefazolin* or cefepime* or cefotaxime* or cefotiam* or cefta*idim* or ceftriaxone* or cefuroxim* or celastin* or cilastin* or ciprofloxacin* or daptomycin* or imip*nem* or imp*nem* or levofloxacin* or linezolid* or meropenem* or metronidazole* or moxifloxacin* or piperacillin* or sulbactam* or tacobactam* or vancomycin*).mp. [mp=title, abstract, original title, name of substance word, subject heading word, floating sub‐heading word, keyword heading word, organism supplementary concept word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier, synonyms] 14. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 15. exp Cholangitis/ 16. exp Cholecystitis/ 17. (cholangit* or cholecystit*).mp. [mp=title, abstract, original title, name of substance word, subject heading word, floating sub‐heading word, keyword heading word, organism supplementary concept word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier, synonyms] 18. 15 or 16 or 17 19. 14 and 18 20. (randomized controlled trial or controlled clinical trial).pt. or clinical trials as topic.sh. or trial.ti. 21. (random* or blind* or placebo* or meta‐analys*).mp. [mp=title, abstract, original title, name of substance word, subject heading word, floating sub‐heading word, keyword heading word, organism supplementary concept word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier, synonyms] 22. 19 and (20 or 21)
Embase Ovid	1974 to April 2020	1. exp antiinfective agent/ 2. exp cephalosporin derivative/ 3. exp ampicillin/ 4. exp ciprofloxacin/ 5. exp daptomycin/ 6. exp imipenem/ 7. exp levofloxacin/ 8. exp linezolid/ 9. exp meropenem/ 10. exp metronidazole/ 11. exp moxifloxacin/ 12. exp sulbactam/ 13. exp vancomycin/ 14. (Ampicillin* or cefazolin* or cefepime* or cefotaxime* or cefotiam* or cefta*idim* or ceftriaxone* or cefuroxim* or celastin* or cilastin* or ciprofloxacin* or daptomycin* or imip*nem* or imp*nem* or levofloxacin* or linezolid* or meropenem* or metronidazole* or moxifloxacin* or piperacillin* or sulbactam* or tacobactam* or vancomycin*).mp. [mp=title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword, floating subheading word, candidate term word] 15. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 16. exp cholangitis/ 17. exp cholecystitis/ 18. (cholangit* or cholecystit*).mp. [mp=title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword, floating subheading word, candidate term word] 19. 16 or 17 or 18 20. 15 and 19 21. Randomized controlled trial/ or Controlled clinical study/ or trial.ti. 22. (random* or blind* or placebo* or meta‐analys*).mp. [mp=title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword, floating subheading word, candidate term word] 23. 20 and (21 or 22)
LILACS (Bireme)	1982 to April 2020	(antibiotic$ or ampicillin$ or cefazolin$ or cefepime$ or cefotaxime$ or cefotiam$ or ceftacidim$ or ceftazidim$ or ceftriaxone$ or cefuroxim$ or celastin$ or cilastin$ or ciprofloxacin$ or daptomycin$ or imipenem$ or imipinem$ or impenem$ or impinem$ or levofloxacin$ or linezolid$ or meropenem$ or metronidazole$ or moxifloxacin$ or piperacillin$ or sulbactam$ or tacobactam$ or vancomycin$) [Words] and (cholangit$ or cholecystit$) [Words]
Science Citation Index Expanded (Web of Science)	1900 to April 2020	#5 #4 AND #3 #4 TI=(random* or blind* or placebo* or meta‐analys* or trial*) OR TS=(random* or blind* or placebo* or meta‐analys*) #3 #2 AND #1 #2 TS=(cholangit* or cholecystit*) #1 TS=(antibiotic* or Ampicillin* or cefazolin* or cefepime* or cefotaxime* or cefotiam* or ceftacidim* or ceftazidim* or ceftriaxone* or cefuroxim* or celastin* or cilastin* or ciprofloxacin* or daptomycin* or imipenem* or imipinem* or impenem* or impinem* or levofloxacin* or linezolid* or meropenem* or metronidazole* or moxifloxacin* or piperacillin* or sulbactam* or tacobactam* or vancomycin*)
Conference Proceedings Citation Index – Science (Web of Science)	1990 to April 2020	#5 #4 AND #3 #4 TI=(random* or blind* or placebo* or meta‐analys* or trial*) OR TS=(random* or blind* or placebo* or meta‐analys*) #3 #2 AND #1 #2 TS=(cholangit* or cholecystit*) #1 TS=(antibiotic* or Ampicillin* or cefazolin* or cefepime* or cefotaxime* or cefotiam* or ceftacidim* or ceftazidim* or ceftriaxone* or cefuroxim* or celastin* or cilastin* or ciprofloxacin* or daptomycin* or imipenem* or imipinem* or impenem* or impinem* or levofloxacin* or linezolid* or meropenem* or metronidazole* or moxifloxacin* or piperacillin* or sulbactam* or tacobactam* or vancomycin*)