Figure 1.

Mice injected with advanced glycation end products (AGEs) show dementia-like behavior. (A,B) Water maze experiment was performed on three groups of mice to observe the dementia-like behavior. (A) The time that the three groups of mice stayed in the target area was measured. (B) The number of times the three groups of mice crossed the platform. The criterion for judging the entry of the mouse into the target area was the entry point of the mouse torso center point. (C) Y-maze experiment measured the residence time of three groups of mice injected with BSA, AGEs, AGEs + LiCl in the brain in the new arm of the Y-maze. (D) Open-field experiment measured the length of stay of the three groups of mice in the central area time. For each group of mice, n = 5. Data are expressed as mean ± standard deviation. One-way analysis of variance (ANOVA). *p < 0.05, **p < 0.01, ***p < 0.001.