Razzaghi 2018.

Study characteristics
Methods	Study design: randomised, double‐blind, placebo‐controlled trial Setting/location: Naghavi Hospital in Kashan, Iran Date: December 2016‐February 2017 Study duration: 12 weeks
Participants	Sample size: n = 70 participants Inclusion criteria: grade 3 DFU according to Wagner‐Meggitt's criteria aged 40–85 years Exclusion criteria: pregnant and breast feeding taking magnesium, multivitamin‐mineral and antioxidant supplements, and antiinflammatory agents change in consuming medications throughout the study history of diseases that influence the development of DFU including chronic trauma Participant characteristics: men: 24 (68.6%) (control), 22 (62.9%) (intervention); women: 11 (31.4%) (control), 13 (37.1%) (intervention) mean age: control: 59.0 ± 10.1; intervention: 60.1 ± 11.1 BMI: control: 26.2 ± 4.1; intervention: 28.2 ± 5.2 wound duration (weeks): not stated baseline wound size (cm): control: 3.6 ± 1.6 (L); 2.9 ± 1.4 (W); 1.3 ± 0.6 (D); intervention: 3.6 ± 2.7 (L); 3.3 ± 2.8 (W); 1.7 ± 1.1 (D)
Interventions	Intervention: 250 mg magnesium oxide supplements Control: placebo daily for 12 weeks
Outcomes	Primary outcome wound healing (reduction in wound length, breadth and width)
Notes	The study was funded by a grant from the Vice Chancellor for Research, Kashan University of Medical Sciences
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "randomization assignment was conducted by using computer‐generated random numbers"
Allocation concealment (selection bias)	Low risk	Quote: "randomization and allocation were concealed from the researchers and participants until the final analyses were completed"
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Quote: "allocation was concealed from the participants until the final analyses were completed"
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Quote: "allocation was concealed from the researchers until the final analyses were completed"
Incomplete outcome data (attrition bias) All outcomes	Low risk	All those randomised were analysed according to ITT
Selective reporting (reporting bias)	Low risk	Study registered and all outcomes reported
Other bias	Low risk	None detected