| 1.1 FEV₁ (L) change from start of treatment |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.1.1 At day 7 |
1 |
23 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.12 [‐0.36, 0.13] |
| 1.1.2 At day 14 |
2 |
68 |
Mean Difference (IV, Fixed, 95% CI) |
0.04 [‐0.08, 0.16] |
| 1.1.3 At 1 month |
1 |
27 |
Mean Difference (IV, Fixed, 95% CI) |
0.17 [‐0.03, 0.37] |
| 1.2 FEV1 (% predicted) change from start of treatment |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.2.1 At day 7 |
1 |
23 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.09 [‐10.60, 4.41] |
| 1.2.2 At day 14 |
1 |
34 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.47 [‐9.29, 4.34] |
| 1.2.3 At 1 month |
1 |
27 |
Mean Difference (IV, Fixed, 95% CI) |
4.93 [‐2.42, 12.28] |
| 1.3 FVC (% predicted) change from start of treatment |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.3.1 At day 7 |
1 |
23 |
Mean Difference (IV, Fixed, 95% CI) |
‐6.35 [‐13.04, 0.34] |
| 1.3.2 At day 14 |
1 |
34 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.27 [‐9.06, 4.51] |
| 1.3.3 At 1 month |
1 |
27 |
Mean Difference (IV, Fixed, 95% CI) |
5.80 [‐4.59, 16.19] |
| 1.4 FVC (L) change from start of treatment |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.4.1 At day 7 |
1 |
23 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.13 [‐0.42, 0.17] |
| 1.4.2 At day 14 |
1 |
34 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.03 [‐0.32, 0.26] |
| 1.4.3 At 1 month |
1 |
27 |
Mean Difference (IV, Fixed, 95% CI) |
0.26 [‐0.07, 0.60] |
| 1.5 Time to next exacerbation (days) |
1 |
|
Hazard Ratio (IV, Fixed, 95% CI) |
Subtotals only |
| 1.6 Pulmonary exacerbations (number of participants) |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.6.1 At end of study |
1 |
39 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.83 [0.57, 1.22] |
| 1.7 Adverse events |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.7.1 Mild |
2 |
73 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.70 [0.48, 1.04] |
| 1.7.2 Moderate |
2 |
73 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.36 [0.07, 1.77] |
| 1.7.3 Severe |
2 |
73 |
Risk Ratio (M‐H, Fixed, 95% CI) |
Not estimable |
| 1.8 Change in P aeruginosa sputum density (log₁₀ CFU/g) |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.8.1 At day 14 |
2 |
70 |
Mean Difference (IV, Fixed, 95% CI) |
0.80 [‐0.59, 2.18] |
| 1.8.2 At 1 month |
1 |
30 |
Mean Difference (IV, Fixed, 95% CI) |
0.35 [‐0.53, 1.23] |
| 1.9 CFQ‐R change from start of treatment |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.9.1 At day 14 |
1 |
38 |
Mean Difference (IV, Fixed, 95% CI) |
‐15.04 [‐28.38, ‐1.71] |
| 1.9.2 At 1 month |
1 |
27 |
Mean Difference (IV, Fixed, 95% CI) |
‐17.03 [‐30.13, ‐3.92] |
