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. 2018 May 25;20(5):421–427. [Article in Chinese] doi: 10.7499/j.issn.1008-8830.2018.05.016

2.

通过cell-SELEX筛选的核酸适体

肿瘤 靶细胞 核酸适体 靶标蛋白 解离常数(nmol/L) 文献
急性淋巴系白血病 CCRF-CEM sgc8 PTK7 0.80±0.09 [33]
急性早幼粒系白血病 HL-60 KH1C12 - 5.4±1.6 [34]
急性早幼粒系白血病 NB4 JH6 Siglec-5 2.77 [35]
弥漫性大B细胞淋巴瘤 Toledo sgd5 - - [36]
伯基特淋巴瘤 Ramos TD05 IGHM 74.7±8.7 [37]
霍奇金淋巴瘤 HDLM2 PS1 - 5.0±0.5 [38]
PS1NP 10.0±0.6
胶质肉瘤 K308 WQY-9-B - 23±5 [39]
胶质细胞瘤 U87Δ aptamer 32 EGFRvIII 0.62±0.04 [40]
胶质细胞瘤 GBM TICs A1, A2, A3 - 0.12~3.75 [41]
A4, A5, A6
胶质细胞瘤 U118 GBM128 - 20±10 [42]
GBM131 37±13
胶质细胞瘤 U87-EGFRvIII U2 EGFRvIII 3.37±0.98 [43]
U8 4.35±1.17
U19 16.78±5.90
U31 8.10±2.36
胶质细胞瘤 U87MG SA43 Ku70 21.6±4.6 [44]
SA44 Ku80 21.1±3.3
胶质细胞瘤 U87MG GL43.T EphB2/3 433.5±136.6 [45]
骨肉瘤 U-2 OS No.6 - - [46]
骨肉瘤 K7M2 LC09 - 22.92 [47]