2.
通过cell-SELEX筛选的核酸适体
肿瘤 | 靶细胞 | 核酸适体 | 靶标蛋白 | 解离常数(nmol/L) | 文献 |
急性淋巴系白血病 | CCRF-CEM | sgc8 | PTK7 | 0.80±0.09 | [33] |
急性早幼粒系白血病 | HL-60 | KH1C12 | - | 5.4±1.6 | [34] |
急性早幼粒系白血病 | NB4 | JH6 | Siglec-5 | 2.77 | [35] |
弥漫性大B细胞淋巴瘤 | Toledo | sgd5 | - | - | [36] |
伯基特淋巴瘤 | Ramos | TD05 | IGHM | 74.7±8.7 | [37] |
霍奇金淋巴瘤 | HDLM2 | PS1 | - | 5.0±0.5 | [38] |
PS1NP | 10.0±0.6 | ||||
胶质肉瘤 | K308 | WQY-9-B | - | 23±5 | [39] |
胶质细胞瘤 | U87Δ | aptamer 32 | EGFRvIII | 0.62±0.04 | [40] |
胶质细胞瘤 | GBM TICs | A1, A2, A3 | - | 0.12~3.75 | [41] |
A4, A5, A6 | |||||
胶质细胞瘤 | U118 | GBM128 | - | 20±10 | [42] |
GBM131 | 37±13 | ||||
胶质细胞瘤 | U87-EGFRvIII | U2 | EGFRvIII | 3.37±0.98 | [43] |
U8 | 4.35±1.17 | ||||
U19 | 16.78±5.90 | ||||
U31 | 8.10±2.36 | ||||
胶质细胞瘤 | U87MG | SA43 | Ku70 | 21.6±4.6 | [44] |
SA44 | Ku80 | 21.1±3.3 | |||
胶质细胞瘤 | U87MG | GL43.T | EphB2/3 | 433.5±136.6 | [45] |
骨肉瘤 | U-2 OS | No.6 | - | - | [46] |
骨肉瘤 | K7M2 | LC09 | - | 22.92 | [47] |