Comparison 2. Condition‐specific quality of life.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Breast cancer change	4		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1.1 Up to 12 weeks' follow‐up	3	224	Mean Difference (IV, Random, 95% CI)	‐0.37 [‐1.93, 1.20]
2.1.2 6 months' follow‐up	2	81	Mean Difference (IV, Random, 95% CI)	0.24 [‐1.60, 2.08]
2.2 Breast cancer follow‐up values	5		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.2.1 Up to 12 weeks' follow‐up	4	331	Mean Difference (IV, Random, 95% CI)	1.21 [‐0.65, 3.07]
2.2.2 6 months' follow‐up	4	307	Mean Difference (IV, Random, 95% CI)	1.45 [0.08, 2.81]
2.3 Overall prostate cancer change	3		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
2.3.1 Up to 12 weeks' follow‐up	3	242	Std. Mean Difference (IV, Random, 95% CI)	0.41 [0.15, 0.67]
2.3.2 More than 12 weeks' to less than 6 months' follow‐up	1	121	Std. Mean Difference (IV, Random, 95% CI)	0.28 [‐0.10, 0.65]
2.4 Overall prostate cancer follow‐up values	3		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
2.4.1 Up to 12 weeks' follow‐up	3	242	Std. Mean Difference (IV, Random, 95% CI)	0.22 [‐0.04, 0.48]
2.4.2 More than 12 weeks' to less than 6 months' follow‐up	1	162	Std. Mean Difference (IV, Random, 95% CI)	0.27 [‐0.04, 0.58]
2.5 FACT prostate cancer subscale change	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.5.1 Up to 12 weeks' follow‐up	2	142	Mean Difference (IV, Random, 95% CI)	2.02 [0.12, 3.93]
2.5.2 More than 12 weeks' to less than 6 months' follow‐up	1	121	Mean Difference (IV, Random, 95% CI)	1.42 [‐0.48, 3.32]
2.6 FACT prostate cancer subscale follow‐up values	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.6.1 Up to 12 weeks' follow‐up	2	142	Mean Difference (IV, Random, 95% CI)	1.91 [‐0.21, 4.03]
2.6.2 More than 12 weeks' to less than 6 months' follow‐up	1	162	Mean Difference (IV, Random, 95% CI)	1.75 [‐0.25, 3.75]
2.7 Expanded Prostate Cancer Index Composite change	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.7.1 Up to 12 weeks' follow‐up	1	100	Mean Difference (IV, Random, 95% CI)	6.75 [1.44, 12.06]
2.8 Expanded Prostate Cancer Index Composite follow‐up values	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.8.1 Up to 12 weeks' follow‐up	1	100	Mean Difference (IV, Random, 95% CI)	1.73 [‐4.19, 7.65]
2.9 QLSI cancer module subscale follow‐up values	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.9.1 Up to 12 weeks' follow‐up	1	64	Mean Difference (IV, Random, 95% CI)	‐0.52 [‐2.24, 1.20]