Skip to main content
. 2012 Aug 15;2012(8):CD008465. doi: 10.1002/14651858.CD008465.pub2

Comparison 8. Fatigue.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
8.1 Overall fatigue change 17   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
8.1.1 Up to 12 weeks' follow‐up 12 971 Std. Mean Difference (IV, Random, 95% CI) ‐0.73 [‐1.14, ‐0.31]
8.1.2 More than 12 weeks' to less than 6 months' follow‐up 2 261 Std. Mean Difference (IV, Random, 95% CI) ‐0.11 [‐0.37, 0.14]
8.1.3 6 months' follow‐up 6 614 Std. Mean Difference (IV, Random, 95% CI) 0.03 [‐0.14, 0.19]
8.2 Overall fatigue follow‐up values 28   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
8.2.1 Up to 12 weeks' follow‐up 23 1721 Std. Mean Difference (IV, Random, 95% CI) ‐0.38 [‐0.57, ‐0.18]
8.2.2 More than 12 weeks' to less than 6 months' follow‐up 10 838 Std. Mean Difference (IV, Random, 95% CI) ‐0.19 [‐0.33, ‐0.05]
8.2.3 6 months' follow‐up 7 633 Std. Mean Difference (IV, Random, 95% CI) ‐0.18 [‐0.35, ‐0.00]
8.3 FACT‐F subscale change 6   Mean Difference (IV, Random, 95% CI) Subtotals only
8.3.1 Up to 12 weeks' follow‐up 4 439 Mean Difference (IV, Random, 95% CI) 5.35 [2.13, 8.56]
8.3.2 More than 12 weeks' to less than 6 months' follow‐up 1 223 Mean Difference (IV, Random, 95% CI) 1.35 [‐1.09, 3.79]
8.3.3 6 months' follow‐up 2 237 Mean Difference (IV, Random, 95% CI) ‐0.13 [‐2.58, 2.32]
8.4 FACT‐F follow‐up values 9   Mean Difference (IV, Random, 95% CI) Subtotals only
8.4.1 Up to 12 weeks' follow‐up 9 884 Mean Difference (IV, Random, 95% CI) 2.79 [0.97, 4.61]
8.4.2 More than 12 weeks' to less than 6 months' follow‐up 3 374 Mean Difference (IV, Random, 95% CI) 2.40 [0.17, 4.64]
8.4.3 6 months' follow‐up 5 471 Mean Difference (IV, Random, 95% CI) 2.02 [0.10, 3.95]
8.5 FACIT‐F subscale change 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.5.1 Up to 12 weeks' follow‐up 1 38 Mean Difference (IV, Random, 95% CI) 4.16 [‐0.31, 8.63]
8.5.2 More than 12 weeks' to less than 6 months' follow‐up 1 38 Mean Difference (IV, Random, 95% CI) 0.01 [‐4.69, 4.71]
8.6 FACIT‐F subscale follow‐up values 3   Mean Difference (IV, Random, 95% CI) Subtotals only
8.6.1 Up to 12 weeks' follow‐up 3 143 Mean Difference (IV, Random, 95% CI) 5.68 [3.62, 7.74]
8.6.2 More than 12 weeks' to less than 6 months' follow‐up 1 38 Mean Difference (IV, Random, 95% CI) 2.82 [‐3.68, 9.32]
8.7 QLQ‐C30 change 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.7.1 Up to 12 weeks' follow‐up 1 44 Mean Difference (IV, Random, 95% CI) ‐0.36 [‐28.87, 28.15]
8.8 QLQ‐C30 fatigue subscale follow‐up values 6   Mean Difference (IV, Random, 95% CI) Subtotals only
8.8.1 Up to 12 weeks' follow‐up 5 411 Mean Difference (IV, Random, 95% CI) ‐7.40 [‐12.19, ‐2.62]
8.8.2 More than 12 weeks' to less than 6 months' follow‐up 3 127 Mean Difference (IV, Random, 95% CI) ‐9.07 [‐18.42, 0.27]
8.8.3 6 months' follow‐up 1 29 Mean Difference (IV, Random, 95% CI) ‐20.00 [‐41.23, 1.23]
8.9 Brief Fatigue Inventory change 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.9.1 Up to 12 weeks' follow‐up 1 38 Mean Difference (IV, Random, 95% CI) ‐0.07 [‐0.83, 0.69]
8.9.2 More than 12 weeks' to less than 6 months' follow‐up 1 38 Mean Difference (IV, Random, 95% CI) ‐0.78 [‐1.91, 0.35]
8.10 Brief Fatigue Inventory follow‐up values 4   Mean Difference (IV, Random, 95% CI) Totals not selected
8.10.1 Up to 12 weeks' follow‐up 3   Mean Difference (IV, Random, 95% CI) Totals not selected
8.10.2 More than 12 weeks' to less than 6 months' follow‐up 3   Mean Difference (IV, Random, 95% CI) Totals not selected
8.11 POMS fatigue subscale change 3   Mean Difference (IV, Random, 95% CI) Subtotals only
8.11.1 Up to 12 weeks' follow‐up 3 378 Mean Difference (IV, Random, 95% CI) ‐0.96 [‐2.39, 0.47]
8.11.2 6 months' follow‐up 1 103 Mean Difference (IV, Random, 95% CI) ‐1.60 [‐11.34, 8.14]
8.12 POMS fatigue subscale follow‐up values 2   Mean Difference (IV, Random, 95% CI) Subtotals only
8.12.1 Up to 12 weeks' follow‐up 2 140 Mean Difference (IV, Random, 95% CI) ‐2.63 [‐8.02, 2.76]
8.12.2 More than 12 weeks' to less than 6 months' follow‐up 1 80 Mean Difference (IV, Random, 95% CI) ‐6.70 [‐11.05, ‐2.35]
8.13 POMS vigor subscale change 2   Mean Difference (IV, Random, 95% CI) Subtotals only
8.13.1 Up to 12 weeks' follow‐up 2 270 Mean Difference (IV, Random, 95% CI) 2.80 [‐3.93, 9.53]
8.13.2 6 months' follow‐up 1 103 Mean Difference (IV, Random, 95% CI) ‐1.10 [‐11.21, 9.01]
8.14 POMS vigor subscale follow‐up values 2   Mean Difference (IV, Random, 95% CI) Subtotals only
8.14.1 Up to 12 weeks' follow‐up 2 140 Mean Difference (IV, Random, 95% CI) 3.04 [0.01, 6.08]
8.14.2 More than 12 weeks' to less than 6 months' follow‐up 1 80 Mean Difference (IV, Random, 95% CI) 2.60 [‐1.74, 6.94]
8.15 Piper Fatigue Scale change 3   Mean Difference (IV, Random, 95% CI) Subtotals only
8.15.1 Up to 12 weeks' follow‐up 2 40 Mean Difference (IV, Random, 95% CI) ‐3.16 [‐5.54, ‐0.77]
8.15.2 More than 12 weeks' to less than 6 months' follow‐up 1 108 Mean Difference (IV, Random, 95% CI) ‐0.60 [‐1.62, 0.42]
8.16 Piper Fatigue Scale follow‐up values 2   Mean Difference (IV, Random, 95% CI) Subtotals only
8.16.1 Up to 12 weeks' follow‐up 1 21 Mean Difference (IV, Random, 95% CI) ‐2.00 [‐3.73, ‐0.27]
8.16.2 More than 12 weeks' to less than 6 months' follow‐up 1 108 Mean Difference (IV, Random, 95% CI) ‐0.20 [‐1.14, 0.74]
8.17 MOS SF‐36 vitality subscale change 2   Mean Difference (IV, Random, 95% CI) Subtotals only
8.17.1 6 months' follow‐up 2 166 Mean Difference (IV, Random, 95% CI) ‐3.93 [‐7.88, 0.03]
8.18 MOS SF‐36 vitality subscale follow‐up values 4   Mean Difference (IV, Random, 95% CI) Subtotals only
8.18.1 Up to 12 weeks' follow‐up 3 345 Mean Difference (IV, Random, 95% CI) 9.64 [5.30, 13.98]
8.18.2 More than 12 weeks' to less than 6 months' follow‐up 1 56 Mean Difference (IV, Random, 95% CI) 4.80 [‐10.73, 20.33]
8.18.3 6 months' follow‐up 1 45 Mean Difference (IV, Random, 95% CI) 0.70 [‐4.74, 6.14]
8.19 Fatigue Severity Scale change 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.19.1 More than 12 weeks' to less than 6 months' follow‐up 1 100 Mean Difference (IV, Random, 95% CI) ‐0.30 [‐0.83, 0.23]
8.20 Fatigue Severity Scale follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.20.1 More than 12 weeks' to less than 6 months' follow‐up 1 100 Mean Difference (IV, Random, 95% CI) ‐0.31 [‐0.84, 0.22]
8.21 Multidimensional Fatigue Inventory follow‐up values 2   Mean Difference (IV, Random, 95% CI) Subtotals only
8.21.1 Up to 12 weeks' follow‐up 2 114 Mean Difference (IV, Random, 95% CI) ‐2.09 [‐3.82, ‐0.35]
8.21.2 More than 12 weeks' to less than 6 months' follow‐up 1 80 Mean Difference (IV, Random, 95% CI) ‐2.50 [‐4.34, ‐0.66]
8.22 Multidimensional Fatigue Inventory physical fatigue subscale follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.22.1 Up to 12 weeks' follow‐up 1 81 Mean Difference (IV, Random, 95% CI) ‐1.70 [‐3.62, 0.22]
8.22.2 More than 12 weeks' to less than 6 months' follow‐up 1 80 Mean Difference (IV, Random, 95% CI) ‐2.60 [‐4.62, ‐0.58]
8.23 Multidimensional Fatigue Inventory reduced activation subscale follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.23.1 Up to 12 weeks' follow‐up 1 81 Mean Difference (IV, Random, 95% CI) ‐0.60 [‐2.41, 1.21]
8.23.2 More than 12 weeks' to less than 6 months' follow‐up 1 81 Mean Difference (IV, Random, 95% CI) ‐0.50 [‐2.38, 1.38]
8.24 Multidimensional Fatigue Inventory reduced motivation subscale follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.24.1 Up to 12 weeks' follow‐up 1 81 Mean Difference (IV, Random, 95% CI) ‐0.50 [‐2.02, 1.02]
8.24.2 More than 12 weeks' to less than 6 months' follow‐up 1 80 Mean Difference (IV, Random, 95% CI) ‐0.40 [‐1.93, 1.13]
8.25 Multidimensional Fatigue Inventory mental fatigue subscale follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.25.1 Up to 12 weeks' follow‐up 1 81 Mean Difference (IV, Random, 95% CI) ‐0.60 [‐2.50, 1.30]
8.25.2 More than 12 weeks' to less than 6 months' follow‐up 1 80 Mean Difference (IV, Random, 95% CI) 0.00 [‐1.78, 1.78]
8.26 Schwartz Fatigue follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.26.1 6 months' follow‐up 1 17 Mean Difference (IV, Random, 95% CI) 0.50 [‐4.26, 5.26]
8.27 LASA change 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.27.1 Up to 12 weeks' follow‐up 1 103 Mean Difference (IV, Random, 95% CI) ‐1.50 [‐12.30, 9.30]
8.27.2 More than 12 weeks' to less than 6 months' follow‐up 1 103 Mean Difference (IV, Random, 95% CI) ‐3.00 [‐13.33, 7.33]
8.28 MDASI‐T fatigue subscale change 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.28.1 Up to 12 weeks' follow‐up 1 40 Mean Difference (IV, Random, 95% CI) ‐2.11 [‐2.57, ‐1.65]
8.29 MDASI‐T fatigue subscale follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.29.1 Up to 12 weeks' follow‐up 1 40 Mean Difference (IV, Random, 95% CI) ‐1.95 [‐3.03, ‐0.87]