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. 2012 Aug 15;2012(8):CD008465. doi: 10.1002/14651858.CD008465.pub2

Arbane 2009.

Study characteristics
Methods Study design: RCT
Number randomized: 51; 25 to the exercise group and 26 to the control group
Study start and stop dates: not reported
Length of intervention: 12 weeks
Length of follow‐up: to end of the intervention
Participants Type cancer: lung cancer
Time since cancer diagnosis: not reported
Time in active treatment: not reported
Inclusion criteria:
  • attending thoracotomy for lung cancer


Eligibility criteria related to interest or ability, or both, to exercise:
  • none reported


Exclusion criteria:
  • none reported


Gender: male
Current age, mean (range) years: 64 (32 to 82) years
Age at cancer diagnosis: not reported
Ethnicity/race: not reported
Education level: not reported
SES: not reported
Employment status: not reported
Comorbidities: not reported
Past exercise history: not reported
On hormone therapy: not reported
Interventions Number of participants assigned to the exercise intervention: not reported. The intervention included:
  • twice daily training plus usual care during hospital stay. After discharge monthly home visits and weekly telephone calls


Type exercise (aerobic/anaerobic): unclear
Intensity of the experimental exercise intervention: not reported
Frequency: twice per day at the clinic and monthly home visits
Duration of individual sessions: not reported
Duration of exercise program: 12 weeks
Total number of exercise sessions: not reported
Format: unclear, appears to be individual
Facility: unclear
Professionally led: not reported
Adherence: not reported
Number of participants assigned to control group: not reported. The control included:
  • usual care


Contamination of control group: not reported
Outcomes No primary outcome was identified.
QoL outcomes included:
  • global HRQoL, assessed using QLQ‐C30


Other outcomes included:
  • quadriceps strength, assessed using magnetic stimulation

  • 6‐minute walking distance


Outcomes were measured at baseline 5 days and 12 weeks. The number of participants in groups at time points was not reported
Subgroup analysis: none
Adverse events: not reported
Notes Country: UK
Funding: none reported
Published as abstract
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk The generation of the random sequence was not described
Allocation concealment (selection bias) Unclear risk Whether the treatment assignment was concealed from study personnel and participants was not described
Blinding of participants and personnel (performance bias)
All outcomes High risk Owing to the nature of the intervention, it was not possible to conceal allocation to the intervention from the participants
Blinding of outcome assessment (detection bias)
All outcomes High risk Allocation to the intervention was not concealed from the study personnel
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Insufficient details provided to determine whether there was any attrition
Selective reporting (reporting bias) Unclear risk Insufficient details provided to assess whether there was selective outcome reporting
Other bias High risk The small sample size, lack of description of the recruitment and selection of study participants, lack of identification of a primary outcome could give rise to additional biases