Banerjee 2007.

Study characteristics
Methods	Study design: RCT Number randomized: 68; 35 to the exercise group and 33 to the control group Study start and stop dates: not reported Length of intervention: 6 weeks Length of follow‐up: to end of the intervention
Participants	Type cancer: breast cancer Stage, n (%) exercise group: Stage II, 16 (46%); Stage III, 19 (54%) control group: Stage II, 10 (43%); Stage III, 13 (57%) Time since cancer diagnosis: not reported Time in active treatment: all patients received 6 weeks of radiation therapy for a total dosage of 50.4 Gy. Some patients apparently received concurrent chemotherapy but how many is not stated since previous chemotherapy and current concomitant chemotherapy are not distinguished Inclusion criteria: "recently operated breast cancer" (not further specified) 30 to 70 years old Zubrod performance status 0 to 2 (ambulatory > 50% of time) 'high school' education treatment plan of radiation therapy or both adjuvant radiation therapy and chemotherapy consent to participate Eligibility criteria related to interest or ability, or both, to exercise: none Exclusion criteria: concurrent medical condition likely to interfere with the treatment major psychiatric disorder, neurologic illness, or autoimmune disorder cardiovascular illness known metastases exposure to other mutagens, smoking, or alcohol within 3 months of pre‐radiation blood donation Gender: female Current age, mean (SD) years: exercise group: 47 (1.1) years control group: 43 (1.5) years Age at cancer diagnosis: not reported Ethnicity/race: not reported Education level: all required to have completed 'high school' SES: not reported Employment status: not reported Comorbidities: not reported Past exercise history: not reported On hormone therapy: not reported
Interventions	35 participants assigned to the exercise intervention, including: integrated yoga program special techniques for cancer patients, including guided imagery of cancer cells, positive thought provocations, and chanting of various sounds Type exercise (aerobic/anaerobic): aerobic and anaerobic Intensity of the experimental exercise intervention: not reported Frequency: not reported Duration of individual sessions: 90 minutes Duration of exercise program: 6 weeks Total number of exercise sessions: not reported Format: group Facility: facility and home practice Professionally led: professionally led by yoga instructors and trainers Adherence: not reported 33 participants assigned to control group, including: supportive counseling and advised to "take light exercise" ‐ described as going on for 6 weeks but no further information provided Contamination of control group: not reported
Outcomes	No primary outcome identified. Outcomes included: anxiety, assessed using the HADS depression, using the HADS psychological stress, assessed using the Perceived Stress Scale DNA damage assessed through blood alkaline single‐cell gel electrophoresis Outcomes were measured at baseline and at 6 weeks: exercise group: n = 35 at baseline, n = 35 at 6 weeks control group: n = 23 at baseline, n = 23 at 6 weeks Subgroup analysis: none Adverse events: not reported
Notes	Country: India Funding: Atomic Energy Radiation Board of India; SVYASA University Bangalore, India; National Medical Research Council, Singapore
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated random number table
Allocation concealment (selection bias)	Low risk	Group assignments sent to clinics of the recruiting hospitals
Blinding of participants and personnel (performance bias) All outcomes	High risk	Owing to the nature of the intervention, it was not possible to conceal allocation to the intervention from the participants
Blinding of outcome assessment (detection bias) All outcomes	High risk	Allocation to the intervention was not concealed from the study personnel
Incomplete outcome data (attrition bias) All outcomes	High risk	All 10 attritions experienced in the study were from the control group. The attrition occurred either immediately after random assignment or during the course of the study
Selective reporting (reporting bias)	Low risk	There appears to be no selective reporting of outcomes
Other bias	Low risk	The trial appears to be free of other problems that could put it at a high risk of bias