Donnelly 2011.

Study characteristics
Methods	Study design: RCT Number randomized: 33; 16 to the exercise group and 17 to the control group Study start and stop dates: recruitment form June 2008 to March 2009 Length of intervention: 12 weeks Length of follow‐up: 6 months
Participants	Type cancer, n (%): gynecologic cancers (ovarian, endometrial, uterine, cervical, or mixed) exercise group: ovarian, 6 (37.5%); endometrial, 6 (37.5%); cervical, 2 (12.5%); mixed, 1 (12.5%) control group: ovarian, 6 (35.3%); endometrial, 5 (29.4%); cervical, 3 (17.6%); mixed, 2 (11.8%) Cancer stage, stage I to III, n (%): exercise group: Stage I, 7 (43.8%); Stage II, 7 (43.8%); Stage III, 2 (12.5%) control group: Stage I, 9 (52.9%); Stage II, 3 (17.6%); Stage III, 5 (29.4%) Time since cancer diagnosis, mean (SD) months: exercise group: 8.7 (9.6) months control group: 8.6 (8.9) months Time in active treatment: some women still receiving treatment  Inclusion criteria: women ≥ 18 years old diagnosis of gynecologic cancer (Stage I to III) completed surgery and either undergoing or completed anticancer treatment within 3 years of diagnosis report of mild to severe fatigue Eligibility criterion related to interest or ability, or both, to exercise: currently sedentary (i.e. vigorous physical activity < 20 minutes/week or moderate physical activity < 60 minutes/week for the past 6 months) was inclusionary Exclusion criteria: current medical or psychiatric illness (i.e. unstable cardiovascular disease, uncontrolled hypertension, diabetes or respiratory disease, severe mental illness, cognitive dysfunction or orthopedic problems) participation in other intervention trials previous diagnosis of cancer another fatigue‐related comorbidity (fibromyalgia, chronic fatigue syndrome, multiple sclerosis, myalgic encephalopathy, lupus, or arthritis) Gender: female Current age, mean (SD) years: exercise group: 53.5 (8.7) years control group: 52.1 (11.8) years Age at cancer diagnosis: not reported Ethnicity/race: not reported Education level: not reported SES: not reported Employment status, n (%): exercise group: full/part‐time, 1 (6.3%); sick leave, 9 (56.3%); housewife, 2 (12.5%); retired, 4 (25.0%) control group: full/part‐time, 3 (17.6%); sick leave, 8 (47.1%); housewife, 2 (11.8%); retired, 4 (23.5%) Comorbidities: not reported Past exercise history: not reported On hormone therapy: not reported
Interventions	16 participants assigned to the exercise intervention, including: physical activity, including walking and strengthening exercises, implemented by an initial, individual face to face consultation with a physical therapist and physical activity consultations guidelines followed by weekly telephone calls for 10 weeks, a final face‐to‐face consultation at week 12, and 2 monthly follow‐up calls Type exercise (aerobic/anaerobic): aerobic Intensity of experimental exercise intervention: moderate Frequency: aim to meet physical activity guidelines (30 minutes of physical activity on at least 5 days per week) Duration of individual sessions: 30 minutes Duration of exercise program: 12 weeks Total number of exercise sessions: maximum of 60 sessions Format: individual Facility: home Professionally led with initial consultation with a professional physical therapist 17 participants assigned to control group, including: usual care telephone calls at same time and length as exercise group Adherence: 44% of all participants, or 58% of all individuals who remained medically unfit to take part Contamination of control group: unclear
Outcomes	Primary outcome: fatigue, assessed using the MFSI‐SF and the FACIT‐F subscale Secondary outcomes: QoL, assessed using the FACT‐G scale depression, assessed using the BDI‐II positive and negative affect, assessed using the PANAS sleep dysfunction, assessed using the PSQI Outcomes were measured at baseline, 12 weeks (end of intervention), and 6‐month follow‐up (9 months after baseline): exercise group: n = 16 at baseline, n = 15 at 12 weeks, n = 12 at 6‐month follow‐up control group: n = 17 at baseline, n = 17 at 12 weeks, n = 17 at 6‐month follow‐up Subgroup analysis: none reported Adverse events: exercise group: lung metastasis (n = 1), pulmonary embolism (n = 1), heart palpitations (n = 1) control group: none reported
Notes	Country: UK Funding: Department of Employment and Learning, Northern Ireland
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated random numbers table was used to generate the allocation sequence
Allocation concealment (selection bias)	Low risk	Allocation was concealed in sequentially numbered opaque envelopes
Blinding of participants and personnel (performance bias) All outcomes	High risk	Owing to the nature of the intervention, it was not possible to conceal allocation to the intervention from the participants
Blinding of outcome assessment (detection bias) All outcomes	High risk	The outcome assessor was blinded to the study allocation
Incomplete outcome data (attrition bias) All outcomes	Low risk	The study used ITT analyses
Selective reporting (reporting bias)	Low risk	There appears to be no selective reporting of outcomes
Other bias	Low risk	The trial appears to be free of other problems that could put it at a high risk of bias