Skip to main content
. 2012 Aug 15;2012(8):CD008465. doi: 10.1002/14651858.CD008465.pub2

Haddad 2011.

Study characteristics
Methods Study design: RCT
Number randomized: 163; 53 to the yoga exercise group, 56 to the stretching exercise group, and 54 to the control group
Study start and stop dates: not reported
Length of intervention: 6 weeks
Length of follow‐up: 1, 3, and 6 months
Participants Type cancer: breast cancer, Stages 0 to III
Time since cancer diagnosis: not reported
Time in active treatment: not reported
Inclusion criteria:
  • breast cancer Stage 0 to III

  • undergoing radiation therapy


Eligibility criteria related to interest or ability, or both, to exercise:
  • none reported


Exclusion criteria:
  • none reported


Gender: female
Current age, mean years: 51.9 years
Age at cancer diagnosis: not reported
Ethnicity/race: not reported
Education level: not reported
SES: not reported
Employment status: not reported
Comorbidities: not reported
Past exercise history: not reported
On hormone therapy: not reported
Interventions 53 participants assigned to the yoga exercise intervention
56 participants assigned to the stretching exercise intervention
Type exercise (aerobic/anaerobic): aerobic or anaerobic
  • yoga: aerobic

  • stretching: anaerobic


Intensity of the experimental exercise intervention: not reported
Frequency: 3 times per week for either yoga or stretching
Duration of individual sessions: not reported
Duration of exercise program: 6 weeks
Total number of exercise sessions: 18 sessions for either yoga or stretching
Format: not reported
Facility: unclear
Professionally led: not reported
Adherence: not reported
54 participants assigned to control group, including:
  • waiting list


Contamination of control group: not reported
Outcomes No primary outcome was identified. QoL outcomes included:
  • fatigue, assessed using the BFI

  • depression, assessed using the CES‐D

  • global QoL, assessed using the MOS SF‐36 and subscales

  • benefit finding, assessed using the Benefit Finding

  • spiritualty, assessed using the FACT‐Sp


Outcomes were measured at baseline, end of treatment (6 weeks), 1, 3, and 6 months following end of treatment:
  • yoga exercise group: n = 53 at baseline and all follow‐up visits

  • stretching exercise group: n = 56 at baseline and all follow‐up visits

  • control group: n = 54 at baseline and all follow‐up visits


Subgroup analysis: not reported
Adverse events: not reported
Notes Country: unclear, investigators from US, India and Germany
Funding: none reported
Published conference abstract
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Generation of allocation sequence was not described
Allocation concealment (selection bias) Unclear risk Whether the treatment assignment was concealed from study personnel and participants was not described
Blinding of participants and personnel (performance bias)
All outcomes High risk Owing to the nature of the intervention, it was not possible to conceal allocation to the intervention from the participants
Blinding of outcome assessment (detection bias)
All outcomes High risk Study personnel and outcome assessors were not masked or blinded to the study interventions
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Insufficient details provided to determine whether there was any attrition
Selective reporting (reporting bias) Unclear risk Insufficient details provided to assess whether there was selective outcome reporting
Other bias Low risk The trial appears to be free of other problems that could put it at a high risk of bias