Moros 2010.

Study characteristics
Methods	Study design: RCT Number randomized: 22; 11 to the exercise group and 11 to the control group Study start and stop dates: not reported Length of intervention: 18 to 22 weeks Length of follow‐up: 10 to 15 days after end of the intervention
Participants	Type cancer: breast cancer, Stages I to III Time since cancer diagnosis: not reported Time in active treatment: not reported Inclusion criteria: postsurgery scheduled to receive chemotherapy Eligibility criteria related to interest or ability, or both, to exercise: did not regularly exercise could not exercise Exclusion criteria: < 65 years old presence of comorbidities, including diabetes, cardiovascular disease, osteoarticular disease Gender: female Current age: age range 38 to 64 years Age at cancer diagnosis: not reported Ethnicity/race: not reported Education level: not reported SES: not reported Employment status: not reported Comorbidities: not reported Past exercise history: not reported On hormone therapy: not reported
Interventions	11 participants assigned to the exercise intervention, including: "dynamic aerobic exercise" adapted individually Type exercise (aerobic/anaerobic): aerobic Intensity of the experimental exercise intervention: 60% to 70% of determined cardiac HR Frequency: 3 times per week Duration of individual sessions: 60 minutes Duration of exercise program: 18 to 22 weeks Total number of exercise sessions: maximum of 66 sessions Format: individual Facility: facility Professionally led by investigators Adherence: 10 participants adhered > 80% 11 participants assigned to control group, including: usual care Contamination of control group: not reported
Outcomes	Outcomes included: functional capacity, assessed using the Karnofsky Scale psychological status, assessed using the General Health Questionnaire global HRQoL, measured using the QLQ‐C30 Outcomes were measured at baseline and postintervention (about 3 months): exercise group: n = 10 at baseline, n = 10 at postintervention control group: n = 7 at baseline n = 7 at postintervention Subgroup analysis: none Adverse events: not reported
Notes	Country: Spain Funding: none reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	The generation of the random sequence was not described
Allocation concealment (selection bias)	Unclear risk	Whether the treatment assignment was concealed from study personnel and participants was not described
Blinding of participants and personnel (performance bias) All outcomes	High risk	Owing to the nature of the intervention, it was not possible to conceal allocation to the intervention from the participants
Blinding of outcome assessment (detection bias) All outcomes	High risk	Study personnel and outcome assessors were not masked or blinded to the study interventions
Incomplete outcome data (attrition bias) All outcomes	High risk	1 participant withdrew from the exercise group and 4 from the control group and were not included in the analyses
Selective reporting (reporting bias)	Low risk	There is no evidence of selective reporting of outcomes
Other bias	Low risk	The trial appears to be free of other problems that could put it at a high risk of bias