Population	Adults with multiple sclerosis, including all subtypes (CIS, RRMS, SPMS, PPMS)
Intervention	All multivariable prognostic models and their validation studies
Comparator	There are no comparators in this review
Outcome	Clinical disease progression, worsening and activity which are measured based on disability, relapses, or conversion to a more advanced disease subtype
Timing	The models are to be used anytime following diagnosis for predicting future disease course
Setting	Any clinical setting where people with multiple sclerosis receive medical care