#	Concept	Searches
1	Concept 1 MS	(exp Multiple Sclerosis/ OR ((multipl* OR disseminated OR insular) ADJ1 sclerosis).ti,ab.) NOT (animals NOT humans).sh. NOT (child NOT adult).sh.
2	2a prognostic/prediction	(exp Prognosis/ AND (exp disease progression/ OR exp Remission, Spontaneous/ OR exp Recurrence/)) OR (predict OR prognos*).ti. OR ((predict* OR prognos*) ADJ3 (recurrence OR progression OR relaps* OR remission OR remitting OR 'multiple sclerosis' OR ms)).ti,ab. OR ((predict* OR prognos*) ADJ3 treat* ADJ3 response).ti,ab. OR ((predict* OR prognos*) ADJ3 disease ADJ3 activity).ti,ab.
3	2b general models	((model* OR decision* OR identif*) ADJ3 (history OR variable* OR multicomponent* OR multivariable* OR multivariate* OR covariate* OR criteria OR criterion OR scor* OR characteristic* OR finding* OR factor* OR rule*)).ti,ab. OR (decision* ADJ6 model*).ti,ab.
4	2c statistical terms	((logistic OR statistic*) ADJ3 model*).ti,ab. OR (decision*.ti,ab. AND exp models, statistical/) OR (Stratification OR Discrimination OR Discriminate OR "c‐statistic" OR "c statistic" OR "Area under the curve" OR AUC OR Calibration OR Indices OR index OR Algorithm OR Multivariable* OR multivariate* OR covariate* OR valid*).ti. OR ((Stratification OR Discrimination OR Discriminate OR "c‐statistic" OR "c statistic" OR "Area under the curve" OR AUC OR Calibration OR Indices OR index OR Algorithm OR Multivariable* OR multivariate* OR covariate* OR valid*).ab. AND (prognos* OR predict*).ti,ab.)
5	3 Outcomes	((disease OR disability OR invalid* OR function* OR outcome OR impairment OR composite OR activity OR severity OR cognitive OR edss OR treatement OR ms OR 'multiple sclerosis' OR brems) ADJ6 (scor* OR scal* OR status OR assess* OR index OR classification)).ti,ab. OR (clinical ADJ3 (assess* OR activity)).ti,ab. OR ((disease OR disabilit* OR risk OR calculat*) ADJ3 (course OR progression)).ti,ab. OR (relaps* ADJ3 (rate OR frequen* OR time OR prognos* OR predict*)).ti,ab. OR (clinical* ADJ3 decision*).ti,ab. OR ((ms OR cdms OR 'multiple sclerosis') ADJ3 (develop* OR course OR progress* OR relaps* OR clinical*)).ti,ab.
		1 AND 2 OR (1 AND (3 OR 4) AND 5)