#	Concept	Searches
1	Concept 1 MS	('multiple sclerosis'/exp/mj OR (ms:ti AND 'multiple sclerosis'/exp) OR (((multipl* OR disseminated OR insular) NEAR/1 sclerosis):ti,ab)) NOT ([animals]/lim NOT [humans]/lim) NOT ('nonhuman'/exp NOT 'human'/exp) NOT 'animal model'/exp NOT ('child'/exp NOT 'adult'/exp) NOT [conference abstract]/lim
2	2a prognostic/prediction	('predictive value'/exp AND 'model'/exp) OR ('prognosis'/exp AND ('disease exacerbation'/exp OR 'recurrent disease'/exp OR 'recurrence risk'/exp OR 'relapse'/exp OR 'remission'/exp)) OR predict*:ti OR prognos*:ti OR ((predict* OR prognos*) NEAR/3 (recurr* OR progress* OR relaps* OR remission OR remitting OR 'multiple sclerosis' OR ms)):ti,ab OR ((predict* OR prognos*) NEAR/3 treat* NEAR/3 response):ti,ab OR ((predict* OR prognos*) NEAR/3 disease NEAR/3 activity):ti,ab
3	2b general models	((model* OR decision* OR identif*) NEAR/3 (history OR variable* OR multicomponent* OR multivariable* OR multivariate* OR covariate* OR criteria OR criterion OR scor* OR characteristic* OR finding* OR factor* OR rule*)):ti,ab OR (decision* NEAR/6 model*):ti,ab
4	2c statistical terms	((logistic OR statistic*) NEAR/3 model*):ti,ab OR (decision*:ti,ab AND 'statistical model'/exp) OR (Stratification OR Discrimination OR Discriminate OR "c‐statistic" OR "c statistic" OR "Area under the curve" OR AUC OR Calibration OR Indices OR index OR Algorithm OR Multivariable* OR multivariate* OR covariate* OR valid*):ti OR ((Stratification OR Discrimination OR Discriminate OR "c‐statistic" OR "c statistic" OR "Area under the curve" OR AUC OR Calibration OR Indices OR index OR Algorithm OR Multivariable* OR multivariate* OR covariate* OR valid*):ab AND (prognos* OR predict*):ti,ab)
5	3 Outcomes	((disease OR disability OR invalid* OR function* OR outcome OR impairment OR composite OR activity OR severity OR cognitive OR edss OR treatement OR ms OR 'multiple sclerosis' OR brems) NEAR/6 (scor* OR scal* OR status OR assess* OR index OR classification)):ti,ab OR (clinical NEAR/3 (assess* OR activity)):ti,ab OR ((disease OR disabilit* OR risk OR calculat*) NEAR/3 (course OR progression)):ti,ab OR (relaps* NEAR/3 (rate OR frequen* OR time OR prognos* OR predict*)):ti,ab OR (clinical* NEAR/3 decision*):ti,ab OR ((ms OR cdms OR 'multiple sclerosis') NEAR/3 (develop* OR course OR progress* OR relaps* OR clinical*)):ti,ab
		#1 AND #2 OR (#1 AND (#3 OR #4) AND #5)