Vonderheid 1987.

Study characteristics
Methods	This was a randomised, double‐blind, within‐participant trial, which lasted 4 weeks.
Participants	The study recruited 6 participants (2 lesions per treatment) with plaque phase MF, MFCG stage nomenclature of 1979 stage IA (T1, Nx, T0, M0), stage IB (T2, Nx, T0, M0), or stage IIA (T2, N1, T0, M0) Demographics of the included participants 3 men and 3 women Mean age (range) = 59.5 years (33 to 68 years) Stages of disease: IA: 1, IB: 1, IIA: 4 0 participants were lost to follow‐up Exclusion criteria of the trial Any topical therapy within 4 weeks prior to the study Any previous systemic cytotoxic therapy Any previous exposure to exogenous interferon or interferon‐inducer History of cardiac disease, pulmonary embolism, or thrombophlebitis History of exposure to radiation in areas of observation
Interventions	The intervention group was given IFN‐α 2b injections 106 units 3 times weekly at 2 representative sites. The control group was given placebo injections with isotonic sterile water 3 times weekly at 2 representative sites.
Outcomes	Outcomes of the trial Common adverse effects of the treatments Percentage of participants demonstrating clearance (defined by clearance of at least 90% of all lesion surfaces, lesions, or tumour size) (assessed 4 weeks after the end of the intervention)
Notes	The funding body and conflicts of interest were not declared. This study was conducted in a tertiary care centre in the USA.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Lesions were allocated by a random code; no further information was given; information was sought, but we received no response.
Allocation concealment (selection bias)	Unclear risk	Information was sought, but we received no response.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	The trial was described as double‐blind for the first part, which we data extracted.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No separate outcome assessor was described.
Incomplete outcome data (attrition bias) All outcomes	Low risk	ITT analysis was carried out. There were no dropouts.
Selective reporting (reporting bias)	Unclear risk	This was unknown. We contacted the corresponding author for additional outcome data, but we received no reply within 4 weeks.
Other bias	Unclear risk	There were insufficient information to permit judgement.