Study	Reason for exclusion
Anonymous 1982	Less than 90% of enrolled participants had Alibert‐Bazin type MF and no subgroup analysis was available.
Anonymous 2000	This study was not a randomised controlled trial.
Argyropoulos 1979	There was no relevant end point according to the protocol report.
Aviles 2015	This study was not a randomised controlled trial.
Bazex 1975	This study was not a randomised controlled trial.
Breneman 1991	There was no relevant end point according to the protocol report.
Cooper 1994	Less than 90% of enrolled participants had Alibert‐Bazin type MF and no subgroup analysis was available.
Currie 1980	Less than 90% of enrolled participants had Alibert‐Bazin type MF and no subgroup analysis was available.
Dang 2007	Less than 90% of enrolled participants had Alibert‐Bazin type MF and no subgroup analysis was available.
Doan 1958	Less than 90% of enrolled participants had Alibert‐Bazin type MF and no subgroup analysis was available.
Dueck 2010	Less than 90% of enrolled participants had Alibert‐Bazin type MF and no subgroup analysis was available.
Duvic 2010	This study was not a randomised controlled trial.
Fawzi 2010	There was not enough information to confirm inclusion criteria and we had no reaction when we attempted to contact the corresponding author.
Fisher 1993	Less than 90% of enrolled participants had Alibert‐Bazin type MF and no subgroup analysis was available.
Foss 2011	This study was not a randomised controlled trial.
Groth 1979	Less than 90% of enrolled participants had Alibert‐Bazin type MF and no subgroup analysis was available.
Heald 2003	This study was not a randomised controlled trial.
JapicCTI‐050041	There was not enough information to confirm inclusion criteria and we had no reply when we attempted to contact the corresponding author.
Kaung 1969	Less than 90% of enrolled participants had Alibert‐Bazin type MF and no subgroup analysis was available.
Kujawska 2003	There was not enough information to confirm inclusion criteria and we had no reply when we attempted to contact the corresponding author.
Kuzel 2010	Less than 90% of enrolled participants had Alibert‐Bazin type MF and no subgroup analysis was available.
Lambert 1986	This study was not a randomised controlled trial.
Lansigan 2010	There was not enough information to abstract data from the publication.
Loescher 1984	This study was not a randomised controlled trial.
Marsden 1968	This study was not a randomised controlled trial.
Moog 2008	This study was not a randomised controlled trial.
NCT00054171	An email response confirmed that the study was not completed. (The Principal Investigator passed away).
NCT00091208	This study was not a randomised controlled trial.
NCT01007448	There was not enough information to confirm inclusion criteria and we had no reaction when we attempted to contact the corresponding author.
NCT01187446	Study terminated due to "business decision". We contacted the corresponding author for results but did not receive a reply.
NCT01386398	This study was withdrawn prior to enrolment according to www.clinicaltrials.gov.
NCT01625455	Study terminated due to difficult recruiting according to www.clinicaltrials.gov.
Neering 1972	Less than 90% of enrolled participants had Alibert‐Bazin type MF and no subgroup analysis was available.
Negro‐Vilar 2007	There was not enough information to confirm inclusion criteria and we had no reply when we attempted to contact the corresponding author.
O'Neill 2013	This study was not a randomised controlled trial.
Olsen 1986	This study was not a randomised controlled trial.
Pan 2007	There was not enough information to confirm inclusion criteria and we had no reply when we attempted to contact the corresponding author.
Peugeot 1995	This was scientific fraud (see Grant 2009).
Plettenberg 2001	This was a report of an ongoing trial; there was not enough information to confirm inclusion criteria and we had no reply when we attempted to contact the corresponding author.
Prince 2010	Less than 90% of enrolled participants had Alibert‐Bazin type MF and no subgroup analysis was available.
Schrag 1997	There was no relevant end point according to the protocol report.
Serri 1990	This study was not a randomised controlled trial.
Shi 2015	This study was not a randomised controlled trial.
Simon 2010	This study explicitly excluded MF.
Thomsen 1977	Less than 90% of enrolled participants had Alibert‐Bazin type MF and no subgroup analysis was available. This was identified by Molin 1979 and retrieved as a reference in the adverse event search.
Thomsen 1979	This study was not a randomised controlled trial.
Thomsen 1989	This study was not a randomised controlled trial.
Touraine 1978	This study was not a randomised controlled trial.
Wain 2005	There was not enough information to confirm inclusion criteria and we had no reply when we attempted to contact the corresponding author.
Wiernik 1998	Less than 90% of enrolled participants had Alibert‐Bazin type MF and no subgroup analysis was available.
Wilson 1995	This study was not a randomised controlled trial.
Zubrod 1960	Less than 90% of enrolled participants had Alibert‐Bazin type MF and no subgroup analysis was available.