NCT03454945.

Study name	Efficacy of doxycycline in the treatment of early stages of mycosis fungoides: a randomizedcControlled yrial
Methods	This is a randomised controlled trial comparing vibramycin vs. UVA + psoralen in patients with mycosis fungoides.
Participants	Inclusion Criteria Age >18 Established diagnosis of classic MF Exclusion Criteria Any variant of MF other than the classic variant Advanced stages of classic MF: Stage IIb, III or IV Pregnant and lactating females Patients with autoimmune diseases e.g. systemic lupus erythematosus (SLE) Patients with solid or haematological malignancies e.g. breast cancer, leukaemia, etc. Patients with any contraindications for doxycycline (e.g. liver disease, kidney disease, photosensitivity, peptic ulcer or patients receiving systemic retinoids). Patients with any contraindication to phototherapy (e.g. any other skin cancers or photosensitivity); or to psoralen (e.g. liver disease)
Interventions	Arm I Oral vibramycin antibiotic100 mg capsule every 12 hours for 3 months Arm II UVA + psoralen 3 sessions per week for 3 months
Outcomes	Primary outcomes of the study Clinical assessment of the extent of the lesions in body surface area at 3 months Secondary outcomes of the study Pathological assessment using immunohistochemistry at 3 months
Starting date	2017
Contact information	Sponsors and collaborators None Investigators Principal Investigator: Hagar El Sayed
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