| Study | Reason for exclusion |
|---|---|
| Andrews 2005 | Mixed patient cohort (9/15 TBI) Physiological end‐point (brain temperature) |
| Cormio 2007 | Mixed patient cohort (12/22 TBI) Physiological end‐point (body temperature) No placebo control group |
| Diringer 2004 | Mixed patient cohort (82/296 TBI) Physiological end‐point (body temperature) No placebo control group |
| Harris 2007 | Mixed patient cohort (8/12 TBI) Physiological end‐point (brain temperature) |
| Hinz 2007 | Mixed patient cohort (5/26 TBI) Physiological end‐point (body temperature) No placebo control group |
| Hoedemaekers 2007 | Physiological end‐point (body temperature) Mixed patient cohort (11/25 TBI) No placebo control group |
| Mayer 2001 | Mixed patient cohort (27/220 TBI) Physiological end‐point (body temperature) No placebo control group |
| Mayer 2004 | Mixed patient cohort (2/47 TBI) Physiological end‐point (body temperature) No placebo control group |
| Price 2003 | Mixed patient cohort (TBI number not specified, total 67) Physiological end‐point (body temperature) |
| Qiu 2006 | No intention‐to‐treat analysis was carried out. After reviewing the study we contacted the authors and they confirmed that they did not carry out an intention‐to‐treat analysis. Loss to follow up: 40 out of the 96 patients randomised did not have death or disability outcome data reported. |
| Qiu 2006a | Intervention: selective brain cooling to brain temperature of 33 ºC to 35 ºC |
| Wang 2004 | Intervention: selective brain cooling to brain temperature of 33 ºC to 35 ºC |
TBI = traumatic brain injury