Table 1.
Shows the efficacy of mefloquine, MMV665807, and niclosamide against E. multilocularis metacestodes and GL cells. Given are the half-maximal concentrations of metacestode damage (PGI-assay) and GL cell viability (CellTiter Glo assay), as well as the minimal inhibitory concentrations (MIC) for the metacestode viability assay (Alamar blue assay). Values represent means from three independent experiments and respective standard deviations. Data concerning mefloquine and MMV665807 were previously published (Stadelmann et al., 2011, 2016). Data concerning niclosamide is unpublished (R. Rufener, Institute of Parasitology, Bern, Switzerland).
| Mefloquine |
MMV665807 |
Niclosamide |
||||
|---|---|---|---|---|---|---|
| Mean (μM) | SD | Mean (μM) | SD | Mean (μM) | SD | |
| Metacestode damage (EC50) | >30 | – | 1.2 | 1.6 | 0.085 | 0.031 |
| Metacestode viability (MIC) | 50 | – | 1.6 | – | 0.3 | – |
| GL cell viability (IC50) | 13.8 | 0.33 | 0.6 | 0.37 | 0.111 | 0.008 |