| Study | Reason for exclusion |
|---|---|
| Daugherty 2014 | Not a randomised study |
| Hong 2012 | Mixed grade III/IV, not randomised |
| Neyns 2009 | Not a randomised study |
| Schuster 2015 | Not a randomised study. Initially planned as a randomised phase II/III study, but due to voluntary attrition of first 16 participants in standard‐of‐care arm, the study was converted to open‐label, single‐arm phase II trial. |
| Sepulveda 2015 | Not a randomised study |
| Solomon 2013 | Not current standard of care |
| van den Bent 2016 | Phase I study, 3 arms but not randomised |
| Wen 2014 | Not a randomised study |
| Wygoda 2002 | Not a randomised study |
| Wygoda 2006 | Intervention not eligible |
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