Table 3.

Predicted pharmacokinetic parameters of lisinopril after IV and oral dose administration

Ethnicity	Protocol	Dose OD (mg)	Cmax (ng/ml)		Tmax (h)		AUC0-t (ng.h/ml)		References
			Observed	Predicted (Mean)	Observed	Predicted (Mean)	Observed	Predicted Min-Max
European	IV dose	2.97	–	182.3	–	0.1	682 ± 156a	403–848.9	[41]
		5.53	–	347.2	–	0.1	1026 ± 123a	753.9–1598
		11.2		707		0.1	1884 ± 107a	1453–3100
Caucasians	Oral (Fasting)	20	86 ± 48	65.52	6.2 ± 1.1	6.15	1231 ± 620b	495–2097.6	[42]
	Oral (Fed)	20	69 ± 19	58.9	6.8 ± 1	7.6	1029 ± 254b	525–2124.7
European	Oral (Fasting)	20	79.8 ± 39.4	69.32	6.5 ± 1.7	5.6	992.8 ± 520a	556.7–2298	[26]

AUC_0-t^a: Area under the curve from time zero to 72 h

AUC_0-t^b: Area under the curve from time zero to 120 h