Table 4.

Predicted pharmacokinetic parameters of lisinopril after different single oral dose administration to pediatric population

* [42], NC** Not Calculated

The pharmacokinetic parameters were predicted at different doses to obtain values in pediatrics, similar to the reference adult values predicted at 20 mg, such as C_max 86 ± 48 (range 38–124) ng/ml, T_max 6.2 ± 1.1 (range 5.1–7.3) h and AUC_0–120 1231 ± 620 (range 611–1851) ng.h/ml. The yellow color indicates falling of lower range of predicted C_max and AUC_0–120 within the range of reference values, Blue color shows falling of lower and mean value of predicted AUC_0–120 in reference range, while green color demonstrates dose at which maximum value of C_max and AUC_0–120 falls in reference range