RevMan Headings	Information to be Recorded:
Methods	Study design:   Method of randomisation:   Concealment of allocation   Blinded: No o     Single o     Double o     Triple o     Unclear o   Power calculation: Number of patients randomised: Number of patients analysed: Number of exclusions post randomisation: Number of withdrawals and reasons: ÒIntention to treatÓ analysis:   Source of funding:      Not stated  o  Pharmaceutical  o   Other o                                    Description:
Participants	Country:                       Setting/Location:                           Number of centres:                      No:                               Age:                                              Sex:   Inclusion criteria:         Exclusion criteria:
Interventions	Treatment(s):   Control /Placebo                             Duration:
Outcomes	Primary outcomes:     Secondary outcomes:
Notes	Add any additional relevant information     Invitation to authors to add and audit review data: not necessary o  no reply o   declined o  extra data provided o review data confirmed o