Table 2.
Significant brain regions showing altered hypothalamus functional connectivity in mTBI patients compared with healthy controls
| Brain region | BA |
Peak MNI coordinates x,y,z (mm) |
t value | Voxels |
|---|---|---|---|---|
| L hypothalamus | ||||
| L fusiform gyrus | 37 | −36,-54,-18 | −4.1003 | 17 |
| L Rolandic operculum | 45 | −45,-12,18 | −4.1043 | 48 |
| R middle frontal gyrus | 9 | 36,24,42 | −3.8419 | 36 |
| R medial superior frontal gyrus | 10 | 12,33,42 | −3.7560 | 27 |
| R hypothalamus | ||||
| R middle frontal gyrus | 9 | 36,33,33 | −4.6247 | 17 |
| R postcentral gyrus | 2 | 24,-39,72 | −4.6080 | 23 |
| L supplementary motor area | 6 | −9,-12,75 | −4.4478 | 18 |
A corrected threshold of p<0.001 determined by Monte Carlo simulation was taken as measuring that there was significant difference between groups. BA Brodmann area; MNI Montreal Neurological Institute; L left; R right; mTBI mild traumatic brain injury