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. 2020 Jul 29;15:44. doi: 10.1186/s13024-020-00387-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Quantitative analyses of BIN1 peptides in dorsolateral prefrontal cortex (DLPFC). The location and sequence of tested BIN1 peptides is shown in the diagram at the top of the figure. Peptides are colored based on the functional domains of the protein. a-f The abundance of each of the 7 peptides from 3 different domains of BIN1 was tested for association with different AD- related pathology traits in human DLPFC using SRM proteomics. The threshold of significance is reported on the Y-axis and is denoted by the horizontal dashed line as the -log of the False Discovery Rate (FDR) value (FDR < 0.05)