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. 2020 Jul 29;15:44. doi: 10.1186/s13024-020-00387-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Association between BIN1 isoforms and AD pathology in brain post-mortem tissue. a Co-immunostaining using an antibody recognizing specifically BIN1 exon 7 in red and a neuronal marker (NeuN) in green in human post-mortem brain tissues for n = 3 AD and n = 4 non-AD subjects. The number of neurons expressing exon 7 and the total number of neurons have been quantified using the software CellProfiler and CellProfiler Analyst. b Co-immunostaining in human post-mortem brain tissues using an antibody recognizing specifically BIN1 exon 7 in red and an astrocyte marker (ALDH1L1) in green for n = 9 AD and n = 9 non-AD subjects. Cells which express both sets of markers have a yellowish color. The number of astrocytes expressing exon 7 and the total number of astrocytes have been quantified using the software CellProfiler and CellProfiler Analyst. A t-test has been used for statistical analysis using Prism software. The thresholds of significance are p < 0.05* and p < 0.005**