| 'Risk of bias' assessment of Perotti 2020 | |||
| Domain | Assessed outcomes | Authors' judgement | Support for judgement |
| Representative study group (selection bias) | Not available | High | 46 participants only |
| Outcome detectors blinded to intervention (detection bias) | Adverse events | High | Not blinded, but awareness of intervention can bias assessment of subjective outcomes |
| Complete outcome assessment/follow‐up (attrition bias) | Adverse events | Low | Assessed and reported for all participants, 7‐day follow‐up |
| Well‐defined study group (reporting bias) | Not available | Low | Study population and intervention well described |
| Well‐defined outcome (reporting bias) | Adverse events | Low | Assessed and reported for all participants, 7‐day follow‐up |
| Well‐defined risk estimates (analyses) | Adverse events | Not available | No analyses performed |
| Important prognostic factors or follow‐up taken adequately into account (confounding) | Not available | High | Not adjusted for confounding factors |
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