Table 1.
Baseline characteristics among CNSD users and non-users
| Characteristics | CNSD non-users (n=146 to 59.3 %) |
CNSD users (n=100 to 40.7 %) |
P value |
| Females, N (%) | 71 (49%) | 66 (66%) | 0.007† |
| Age at screening, mean (SD) | 75.3 (6.4) | 78.6 (6.5) | <0.001* |
| Education, mean (SD) | 13.6 (2.9) | 12.6 (3.2) | 0.011* |
| AUDIT, mean (SD) | 2.7 (3.2) | 2.2 (3.1) | 0.171* |
| Smoking, N (% No) | 105 (72%) | 70 (70%) | 0.692† |
| HADS depression, mean (SD) HADS anxiety, mean (SD) HADS total score, mean (SD) |
3.6 (3.0) 4.1 (3.3) 7.7 (5.3) |
5.1 (3.5) 5.0 (3.9) 10.1 (6.7) |
<0.001* 0.094* 0.003* |
| CIRS-G mean (SD) | 4.7 (2.1) | 7.7 (2.7) | <0.001* |
| Cognistat mean, (SD)** | 71.5 (5.9) | 66.5 (7.7) | ‡ |
| MMSE mean, (SD)** | 25.7 (2.7) | 24.8 (2.6) | ‡ |
| Clock mean, (SD)** | 4.2 (1.3) | 3.4 (1.4) | ‡ |
| TMT-A, mean (sec), (SD) | 78.6 (48.2) | 90.9 (51.2) | ‡ |
| TMT-B, mean (sec), (SD) | 181.3 (100.6) | 214.9 (107.0) | ‡ |
**p value ≤0.05. The data is presented as mean and SD or number of patients (N) and percentage (%).
*t-test table 2
†χ2 (Missing: CIRS-G=1, HADS=17, smoking=40, education=10, AUDIT=22). The Neurobehavioural Cognitive Status Examination (Cognistat)=145; MMSE=33; Clock drawing test (Clock)=88 TMT A and B=133/139).
‡p value presented in table 2 in bivariate model.
AUDIT, alcohol use and disorder identification test; CIRS-G, cumulative illness rating score geriatrics; CNSD, central nervous system depressant; HADS, hospital anxiety and depression scale; MMSE, mini-mental state examination; sec, secondary; TMT, trail making test.