Table 3.
Screening characteristics of the total study population
| Included (n=297) |
Excluded (n=109) |
P value (t-test) |
|
| Age (years) | 66.5 (7.1) | 68.1 (7.7) | 0.061 |
| Female (%) | 230 (77) | 80 (71) | 0.013 |
| BMI (kg/m2) | 28.1 (5.3) | 26.4 (4.4) | 0.003 |
| Adapted KOOS* | |||
| Stiffness | 38.5 (21.6) | 24.3 (18.5) | <0.001 |
| Pain | 31.3 (19.7) | 17.7 (14.6) | <0.001 |
| Function | 32.9 (19.1) | 19.6 (16.3) | <0.001 |
| Total | 33.1 (18.8) | 19.6 (15.4) | <0.001 |
| NRS pain last week (0–10) | |||
| Index knee | 4.6 (2.8) | 2.6 (2.2) | <0.001 |
| Contralateral knee | 2.8 (2.5) | 1.6 (2.2) | <0.001 |
| KIDA | |||
| Mean JSW index knee (mm) | 5.5 (1.0) | 5.5 (1.1) | 0.700 |
| Minimum JSW index knee (mm) | 2.5 (1.3) | 2.1 (1.0) | 0.001 |
| KL grade (%) | ND | NA | |
| Grade 0 | 51 (17) | |
|
| Grade 1 | 90 (30) | ||
| Grade 2 | 88 (30) | ||
| Grade 3 | 54 (18) | ||
| Grade 4 | 10 (3) | ||
Continuous variables are given as mean values, SD between brackets and categorical variables as total number, percentages between brackets. Differences between included and excluded patients were evaluated using t-tests and Χ2 test (gender).
*A number of KOOS questions was used, weighted to provide a score for stiffness, pain and function of 0 (most severe) to 100 (no limitations).
BMI, body mass index; JSW, joint space width; KIDA, knee image digital analysis; KL, Kellgren and Lawrence; KOOS, Knee injury and Osteoarthritis Outcome Score; NA, not applicable; ND, not determined; NRS, Numeric Rating Scale.