Table 3.
Univariate and multivariate analyses of factors associated with lateral lymph node metastasis in 1773 PTC patients
| Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|
| LLNM (−) | LLNM (+) | P value | Adjusted OR (95% CI) | P value | |
| n = 948 | n = 825 | ||||
| Sex | < 0.001* | ||||
| Female | 713 (75.2%) | 547 (66.3%) | |||
| Male | 235 (24.8%) | 278 (33.7%) | 1.486 (1.184–1.867) | < 0.001* | |
| Age | 0.536 | ||||
| < = 55 | 673 (85.4%) | 616 (84.3%) | |||
| > 55 | 115 (14.6%) | 115 (15.7%) | |||
| Size (cm) | < 0.001* | ||||
| ≤ 1 | 549 (57.9%) | 313 (37.9%) | |||
| 1~2 | 291 (30.7%) | 333 (40.4%) | 1.707 (1.359–2.144) | < 0.001* | |
| > 2 | 108 (11.4%) | 179 (21.7%) | 2.496 (1.844–3.380) | < 0.001* | |
| Location | < 0.001 | ||||
| Upper | 289 (30.5%) | 335 (40.6%) | 2.136 (1.707–2.672) | < 0.001* | |
| Non-upper | 659 (69.5%) | 490 (59.4%) | |||
| ETE | 160 (16.9%) | 215 (26.1%) | < 0.001* | 1.332 (1.031-1.72) | 0.028* |
| Multifocality | 152 (16.0%) | 160 (19.4%) | 0.064 | ||
| Hashimoto | 136 (14.3%) | 111 (13.5%) | 0.589 | ||
| CLNM | 511 (53.9%) | 686 (83.2%) | < 0.001* | 4.172 (3.279–5.308) | < 0.001 |
*Symbol for p < 0.05
ETE extrathyroidal extension, CLNM central lymph node metastasis, LLNM lateral lymph node metastasis, OR odds ratio, CI confidence interval