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. 2012 Jul 11;2012(7):CD010003. doi: 10.1002/14651858.CD010003

Comparison 8. Splint versus oral steroid.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Adverse effects 1 71 Risk Ratio (M‐H, Fixed, 95% CI) 4.86 [0.24, 97.86]
2 Short‐term improvement in CTS symptom severity (Levine) (3 months or less) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
2.1 At end of 4 weeks treatment 1 71 Mean Difference (IV, Fixed, 95% CI) 0.21 [‐0.02, 0.44]
2.2 At 8 weeks post‐treatment 1 71 Mean Difference (IV, Fixed, 95% CI) 0.25 [‐0.03, 0.53]
3 Short‐term improvement in functional status (Levine) (3 months or less) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
3.1 At the end of 4 weeks treatment 1 71 Mean Difference (IV, Fixed, 95% CI) 0.12 [‐0.05, 0.29]
3.2 At 8 weeks post‐treatment 1 71 Mean Difference (IV, Fixed, 95% CI) 0.12 [‐0.06, 0.30]
4 Short‐term improvement in median nerve motor distal latency (ms) (3 months or less) 2   Mean Difference (IV, Random, 95% CI) Subtotals only
4.1 At the end of 4 weeks treatment 1 71 Mean Difference (IV, Random, 95% CI) 0.14 [‐0.18, 0.46]
4.2 At the end of 6 weeks treatment 1 43 Mean Difference (IV, Random, 95% CI) 0.29 [‐0.34, 0.92]
4.3 At 8 weeks post‐treatment 1 71 Mean Difference (IV, Random, 95% CI) 0.27 [‐0.03, 0.57]
5 Short‐term improvement in median nerve sensory distal latency (ms) (3 months or less) 2   Mean Difference (IV, Random, 95% CI) Subtotals only
5.1 At the end of 4 weeks treatment 1 71 Mean Difference (IV, Random, 95% CI) 0.33 [‐0.06, 0.72]
5.2 At the end of 6 weeks treatment 1 43 Mean Difference (IV, Random, 95% CI) 0.20 [‐0.18, 0.58]
5.3 At 8 weeks post‐treatment 1 71 Mean Difference (IV, Random, 95% CI) 0.56 [0.28, 0.84]
6 Short‐term improvement in motor nerve conduction velocity (m/s) (3 months or less) 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
6.1 At the end of 4 weeks treatment 1 71 Mean Difference (IV, Fixed, 95% CI) ‐0.14 [‐3.84, 3.56]
6.2 At the end of 6 weeks treatment 1 43 Mean Difference (IV, Fixed, 95% CI) 2.07 [‐0.74, 4.88]
6.3 At 8 weeks post‐treatment 1 71 Mean Difference (IV, Fixed, 95% CI) ‐3.28 [‐6.35, ‐0.21]
7 Short‐term improvement in sensory nerve conduction velocity (m/s) (3 months or less) 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
7.1 At the end of 4 weeks treatment 1 71 Mean Difference (IV, Fixed, 95% CI) 0.65 [‐3.02, 4.32]
7.2 At the end of 6 weeks treatment 1 43 Mean Difference (IV, Fixed, 95% CI) ‐2.92 [‐9.34, 3.50]
7.3 At 8 weeks post‐treatment 1 71 Mean Difference (IV, Fixed, 95% CI) ‐3.95 [‐7.60, ‐0.30]