Summary of findings 8. Wound closure with the use of autologous platelet concentrates versus conventional method after the removal of mandibular wisdom teeth.
| Wound closure with blood product compared to conventional method after the removal of mandibular wisdom teeth | ||||||
|
Population: adults with mandibular third molars requiring removal Setting: oral surgery Intervention: wound closure with blood products (PRF) Comparison: conventional method | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | Number of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| None | PRP/PRF | |||||
|
Alveolar osteitis (up to 1‐week follow‐up) |
205 per 1000 | 91 per 1000 (54 to 147) | OR 0.39 (0.22 to 0.67) |
128 (2 studies) |
⊕⊕⊝⊝ low1 | Favours PRF |
|
Wound infection (up to 1‐week follow‐up) |
Not reported | |||||
|
Permanent altered tongue, chin, or lip sensation (more than 6 months) |
Not reported | |||||
|
Adverse effects ‐ reactionary bleeding (up to 30 days) |
Not reported | |||||
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; OR: odds ratio; PRP: platelet rich plasma; PRF: platelet rich fibrin | ||||||
|
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate; the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited; the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate; the true effect is likely to be substantially different from the estimate of effect. | ||||||
1Certainty of evidence downgraded two levels because both studies were small, with one at high risk of bias and one unclear.